| Local | Visita | Hora | |
|---|---|---|---|
| Viernes 01 de Diciembre | |||
| Kitara | VS | NEC Nijmegen | 05:00 |
| Chaves | 2 - 1 | Vizela | 14:30 |
| SV Darmstadt 98 | 0 - 1 | FC Koln | 13:30 |
| Heerenveen | 3 - 0 | Almere City FC | 13:00 |
| Monza | 1 - 2 | Juventus | 13:45 |
| Reims | 2 - 1 | Strasbourg | 14:00 |
| FC Schalke 04 | 4 - 0 | VfL Osnabruck | 11:30 |
| FC St. Pauli | 2 - 2 | Hamburger SV | 11:30 |
| Chasselay MDA | POSP | Dijon | 12:30 |
| Colon Santa Fe | VS | Gimnasia L.P. | 14:00 |
| Las Palmas | 2 - 0 | Getafe | 14:00 |
| Groningen | 2 - 1 | VVV Venlo | 13:00 |
| Dordrecht | 2 - 0 | Roda | 13:00 |
| MVV | 4 - 0 | Jong AZ | 13:00 |
| Willem II | 3 - 0 | Emmen | 13:00 |
| FC OSS | 0 - 1 | De Graafschap | 13:00 |
| Helmond Sport | 3 - 2 | ADO Den Haag | 13:00 |
| Cambuur | 2 - 2 | FC Eindhoven | 13:00 |
| Oviedo | 2 - 0 | Espanyol | 13:30 |
| Sportivo Luqueno | 1 - 1 | Nacional Asuncion | 16:30 |
| Cerro Porteño | 4 - 0 | Club Guarani | 16:30 |
| General Caballero | 0 - 1 | Olimpia | 16:30 |
| Coquimbo Unido | 1 - 2 | Union La Calera | 17:00 |
