| Local | Visita | Hora | |
|---|---|---|---|
| Jueves 30 de Noviembre | |||
| Maccabi Haifa | 0 - 3 | Rennes | 11:45 |
| Atalanta | 1 - 1 | Sporting CP | 11:45 |
| Sparta Praha | 1 - 0 | Real Betis | 11:45 |
| AEK Athens FC | 0 - 1 | Brighton | 11:45 |
| Baka Topola | 0 - 1 | West Ham | 11:45 |
| SC Freiburg | 5 - 0 | Olympiakos Piraeus | 11:45 |
| BK Hacken | 0 - 2 | Bayer Leverkusen | 14:00 |
| Servette FC | 1 - 1 | AS Roma | 14:00 |
| Villarreal | 3 - 2 | Panathinaikos | 14:00 |
| Toulouse | 0 - 0 | Union St. Gilloise | 14:00 |
| Liverpool | 4 - 0 | Lask Linz | 14:00 |
| Marseille | 4 - 3 | Ajax | 14:00 |
| AZ Alkmaar | 1 - 0 | Zrinjski | 11:45 |
| Olimpija | 0 - 2 | Lille | 11:45 |
| Eintracht Frankfurt | 1 - 2 | PAOK | 14:00 |
| Fiorentina | 2 - 1 | Genk | 14:00 |
| Aston Villa | 2 - 1 | Legia Warszawa | 14:00 |
| Cerro Largo | 0 - 0 | Cerro | 14:30 |
| La Luz | 0 - 1 | Nacional | 17:30 |
| Puebla | 2 - 2 | Tigres UANL | 19:00 |
| Guadalajara Chivas | 1 - 0 | U.N.A.M. - Pumas | 21:05 |
| Atlante FC | 0 - 0 | Cancún | 19:00 |
| Resistencia | 0 - 3 | Sportivo Ameliano | 17:30 |
| Gremio | 2 - 1 | Goias | 16:00 |
| Cruzeiro | 1 - 1 | Atletico Paranaense | 17:00 |
| Bragantino | 1 - 2 | Fortaleza EC | 17:30 |
| America de Cali | 0 - 1 | Atletico Nacional | 17:15 |
| Independiente Medellin | 2 - 1 | Millonarios | 19:30 |
