| Domingo 26 de Noviembre |
| O Elvas | 1 - 1 | Santa Clara | 05:00 |
| Estoril | 2 - 1 | Mafra | 11:00 |
| Sporting CP | 8 - 0 | Dumiense | 12:00 |
| Arouca | 2 - 2 | Boavista | 14:00 |
| FC Heidenheim | 0 - 0 | VfL BOCHUM | 08:30 |
| 1899 Hoffenheim | 1 - 1 | FSV Mainz 05 | 10:30 |
| River Plate | 1 - 0 | La Luz | 13:30 |
| Nacional | 3 - 1 | Wanderers | 16:30 |
| Almere City FC | 0 - 5 | Heracles | 05:15 |
| Cagliari | 1 - 1 | Monza | 05:30 |
| Nice | 1 - 0 | Toulouse | 06:00 |
| NEC Nijmegen | 1 - 1 | GO Ahead Eagles | 07:30 |
| AZ Alkmaar | 3 - 0 | FC Volendam | 07:30 |
| Empoli | 3 - 4 | Sassuolo | 08:00 |
| Montpellier | 1 - 3 | Stade Brestois 29 | 08:00 |
| Nantes | 0 - 0 | LE Havre | 08:00 |
| Tottenham | 1 - 2 | Aston Villa | 08:00 |
| Lorient | 2 - 3 | Metz | 08:00 |
| Frosinone | 2 - 1 | Genoa | 08:00 |
| Sparta Rotterdam | 1 - 2 | Utrecht | 09:45 |
| Rennes | 3 - 1 | Reims | 10:05 |
| Everton | 0 - 3 | Manchester United | 10:30 |
| AS Roma | 3 - 1 | Udinese | 11:00 |
| Lyon | 0 - 2 | Lille | 13:45 |
| Juventus | 1 - 1 | Inter | 13:45 |
| SpVgg Greuther Furth | 2 - 0 | SV Wehen | 06:30 |
| FC Kaiserslautern | 0 - 3 | Holstein Kiel | 06:30 |
| Villarreal | 3 - 1 | Osasuna | 07:00 |
| Real Sociedad | 2 - 1 | Sevilla | 09:15 |
| Cadiz | 0 - 3 | Real Madrid | 11:30 |
| Real Betis | 1 - 0 | Las Palmas | 14:00 |
| Talleres Cordoba | 3 - 2 | Independiente | 15:00 |
| River Plate | 0 - 0 | Instituto Cordoba | 15:00 |
| Arsenal Sarandi | 1 - 2 | Rosario Central | 15:00 |
| Atletico Tucuman | 0 - 2 | Huracan | 15:00 |
| Godoy Cruz | 1 - 2 | Boca Juniors | 18:30 |
| Crotone | 2 - 1 | Potenza | 09:15 |
| Roda | 1 - 0 | MVV | 05:15 |
| VfB Lubeck | 2 - 2 | Arminia Bielefeld | 06:30 |
| Leganes | 2 - 2 | Racing Ferrol | 07:00 |
| Elche | 2 - 0 | Amorebieta | 09:15 |
| Espanyol | 2 - 0 | Alcorcon | 14:00 |
| Cancún | 3 - 2 | Mineros de Zacatecas | 17:00 |
| Leon | 3 - 2 | Santos Laguna | 20:06 |
| Nacional Asuncion | 1 - 1 | Cerro Porteño | 16:00 |
| A. Italiano | 0 - 1 | Colo Colo | 15:00 |
| Deportes Copiapo | 1 - 1 | Nublense | 17:30 |
| Curico Unido | 3 - 4 | Magallanes | 17:30 |
| Cumbayá | 1 - 2 | LDU de Quito | 17:00 |
| Barcelona SC | 2 - 1 | Guayaquil City FC | 17:00 |
| Gualaceo SC | 0 - 2 | Emelec | 17:00 |
| Tecnico Universitario | 1 - 1 | Libertad | 17:00 |
| Tacuarembo | 0 - 1 | Cerrito | 13:30 |
| Atenas | 0 - 2 | Rentistas | 15:00 |
| Atletico-MG | 3 - 0 | Gremio | 13:00 |
| Botafogo | 1 - 1 | Santos | 13:00 |
| America Mineiro | 0 - 3 | Flamengo | 15:30 |
| Fortaleza EC | 2 - 2 | Palmeiras | 15:30 |
| Internacional | 1 - 0 | Bragantino | 15:30 |
| Sao Paulo | 0 - 0 | Cuiaba | 15:30 |
| Millonarios | 1 - 0 | Independiente Medellin | 15:00 |
| Atletico Nacional | 1 - 0 | America de Cali | 17:30 |
| Houston Dynamo | 1 - 0 | Sporting Kansas City | 18:00 |
| Seattle Sounders | 0 - 1 | Los Angeles FC | 20:30 |
| Deportivo Maipu | 1 - 1 | Estudiantes de Rio Cuarto | 14:00 |
| Almirante Brown | 0 - 2 | Deportivo Riestra | 14:00 |
