| Local | Visita | Hora | |
|---|---|---|---|
| Miércoles 15 de Noviembre | |||
| Rwanda | 0 - 0 | Zimbabwe | 07:00 |
| Congo DR | 2 - 0 | Mauritania | 10:00 |
| Ethiopia | 0 - 0 | Sierra Leone | 13:00 |
| Belgium | 1 - 0 | Serbia | 13:45 |
| North Korea | VS | Syria | 18:00 |
| Colo Colo | 2 - 2 | River Plate | 17:00 |
| Israel | 1 - 1 | Switzerland | 13:45 |
| Millonarios | 1 - 1 | Atletico Nacional | 19:00 |
| Cerro | 1 - 1 | Defensor Sporting | 13:30 |
| Deportivo Maldonado | 3 - 0 | Wanderers | 16:00 |
| Nacional | 1 - 3 | Danubio | 18:30 |
| Cimarrones | 2 - 0 | Atlante FC | 21:05 |
| Monarcas | 2 - 1 | Leones Negros UDG | 19:05 |
| Oriental | 1 - 4 | Rentistas | 07:00 |
| SUD America | 2 - 1 | Albion FC | 13:30 |
| Cerrito | 2 - 1 | Bella Vista | 15:00 |
