| Viernes 10 de Noviembre |
| Atlas | 0 - 0 | Necaxa | 19:00 |
| Inter Miami | 1 - 2 | New York City FC | 19:00 |
| Mazatlán | 1 - 0 | Toluca | 19:06 |
| Club Tijuana | 2 - 3 | Pachuca | 21:10 |
| Liverpool | 3 - 0 | Cerro Largo | 13:30 |
| Torque | 2 - 2 | Plaza Colonia | 16:00 |
| Defensor Sporting | 3 - 0 | Racing Montevideo | 18:30 |
| Borussia Monchengladbach | 4 - 0 | VfL Wolfsburg | 13:30 |
| Estoril | 4 - 0 | Casa Pia | 14:15 |
| Sassuolo | 2 - 2 | Salernitana | 11:30 |
| Fortuna Sittard | 4 - 1 | Heracles | 13:00 |
| Genoa | 1 - 0 | Verona | 13:45 |
| Montpellier | 0 - 0 | Nice | 14:00 |
| FC Schalke 04 | 1 - 2 | SV Elversberg | 11:30 |
| Orleans | 1 - 2 | Dijon | 12:30 |
| Versailles | 6 - 0 | Nimes | 12:30 |
| Venezia | 2 - 1 | Catanzaro | 13:30 |
| Athletic Club | 4 - 3 | Celta Vigo | 14:00 |
| FC Eindhoven | 0 - 2 | VVV Venlo | 13:00 |
| FC OSS | 0 - 1 | MVV | 13:00 |
| Willem II | 2 - 1 | Jong Utrecht | 13:00 |
| NAC Breda | 1 - 1 | Jong Ajax | 13:00 |
| Emmen | 1 - 0 | Den Bosch | 13:00 |
| Telstar | 1 - 2 | De Graafschap | 13:00 |
| Leganes | 2 - 1 | Levante | 13:30 |
| Tijuana W | 1 - 2 | Monterrey W | 18:06 |
| Pumas UNAM W | 1 - 3 | Tigres UANL W | 20:00 |
| Orense SC | 1 - 0 | Mushuc Runa SC | 18:00 |
| Durango | 2 - 1 | Leones Negros | 20:00 |
| Central Cordoba de Santiago | 0 - 1 | Estudiantes L.P. | 16:00 |
| Gimnasia L.P. | 1 - 2 | Atletico Tucuman | 18:00 |
| Seattle Sounders | 1 - 0 | FC Dallas | 21:00 |
