| Miércoles 08 de Noviembre |
| Crotone | 1 - 0 | Brindisi | 07:00 |
| Lecco | 0 - 0 | Spezia | 11:30 |
| Sportivo Trinidense | 2 - 0 | Club Guarani | 16:30 |
| Monterrey | 3 - 0 | Santos Laguna | 20:00 |
| Emmen | 4 - 0 | Goldau | 13:15 |
| Tecnico Universitario | 0 - 2 | LDU de Quito | 18:00 |
| America Mineiro | 0 - 3 | Coritiba | 16:00 |
| Internacional | 0 - 0 | Fluminense | 16:00 |
| Atletico Paranaense | 1 - 1 | Fortaleza EC | 17:00 |
| Sao Paulo | 1 - 0 | Bragantino | 17:00 |
| Flamengo | 3 - 0 | Palmeiras | 18:30 |
| Napoli | 1 - 1 | Union Berlin | 11:45 |
| Real Madrid | 3 - 0 | SC Braga | 14:00 |
| Real Sociedad | 3 - 1 | Benfica | 11:45 |
| Red Bull Salzburg | 0 - 1 | Inter | 14:00 |
| FC Copenhagen | 4 - 3 | Manchester United | 14:00 |
| Bayern Munich | 2 - 1 | Galatasaray | 14:00 |
| PSV Eindhoven | 1 - 0 | Lens | 14:00 |
| Arsenal | 2 - 0 | Sevilla | 14:00 |
| San Lorenzo | 1 - 1 | Boca Juniors | 16:00 |
| Alianza Lima | 0 - 2 | Universitario | 19:00 |
| Jaguares | 0 - 1 | Rionegro Aguilas | 18:30 |
| La Equidad | 2 - 1 | Millonarios | 18:30 |
| America de Cali | 1 - 2 | Bucaramanga | 18:30 |
| Atletico Nacional | 2 - 3 | Deportes Tolima | 18:30 |
| Union Magdalena | 0 - 4 | Independiente Medellin | 18:30 |
| New England Revolution | 0 - 1 | Philadelphia Union | 18:00 |
| Atletico DE Rafaela | 0 - 0 | Estudiantes de Rio Cuarto | 18:05 |
