| Martes 07 de Noviembre |
| Ferro Carril | 0 - 0 | Cerro | 17:00 |
| Guairena FC | 2 - 2 | Sportivo Ameliano | 15:00 |
| Olimpia | 2 - 1 | Sportivo Luqueno | 17:30 |
| Magallanes | 1 - 2 | Colo Colo | 15:00 |
| Borussia Dortmund | 2 - 0 | Newcastle | 11:45 |
| AC Milan | 2 - 1 | Paris Saint Germain | 14:00 |
| Shakhtar Donetsk | 1 - 0 | Barcelona | 11:45 |
| FC Porto | 2 - 0 | Antwerp | 14:00 |
| Lazio | 1 - 0 | Feyenoord | 14:00 |
| Atletico Madrid | 6 - 0 | Celtic | 14:00 |
| FK Crvena Zvezda | 1 - 2 | RB Leipzig | 14:00 |
| Manchester City | 3 - 0 | BSC Young Boys | 14:00 |
| Envigado | 1 - 1 | Deportivo Pasto | 18:30 |
| Chico | 1 - 1 | Deportivo Cali | 18:30 |
| Santa Fe | 0 - 1 | Once Caldas | 18:30 |
| Alianza Petrolera | 2 - 1 | Deportivo Pereira | 18:30 |
| Junior | 2 - 0 | Huila | 18:30 |
| Atlanta United FC | 4 - 2 | Columbus Crew | 18:00 |
| Nashville SC | 0 - 1 | Orlando City SC | 20:00 |
| Deportivo Riestra | 1 - 1 | Estudiantes de Rio Cuarto | 12:30 |
