| Local | Visita | Hora | |
|---|---|---|---|
| Lunes 06 de Noviembre | |||
| Atenas | 2 - 2 | Liverpool | 18:00 |
| Deportivo Maldonado | 1 - 2 | Danubio | 16:00 |
| Paços de Ferreira | 1 - 0 | Academico Viseu | 12:00 |
| Farense | 2 - 0 | Arouca | 14:15 |
| Frosinone | 2 - 1 | Empoli | 11:30 |
| Torino | 2 - 1 | Sassuolo | 13:45 |
| Tottenham | 1 - 4 | Chelsea | 14:00 |
| Getafe | 1 - 0 | Cadiz | 14:00 |
| Jong Ajax | 1 - 0 | Willem II | 13:00 |
| FC OSS | 1 - 8 | Cambuur | 13:00 |
| MVV | 1 - 1 | Emmen | 13:00 |
| FC Eindhoven | 1 - 1 | Roda | 13:00 |
| Jong PSV | 1 - 2 | ADO Den Haag | 13:00 |
| Guingamp | 2 - 1 | Auxerre | 13:45 |
| Querétaro W | 0 - 0 | Mazatlán W | 17:06 |
| Libertad | 1 - 1 | Cerro Porteño | 15:00 |
| Nacional Asuncion | 5 - 0 | Resistencia | 17:30 |
| Universidad de Chile | 1 - 2 | Everton de Vina | 16:00 |
| Universidad Catolica | 0 - 0 | Libertad | 18:00 |
| Vasco DA Gama | 1 - 0 | Botafogo | 16:00 |
| Santos | 0 - 0 | Cuiaba | 18:00 |
| Barracas Central | 1 - 1 | Rosario Central | 15:30 |
| Godoy Cruz | 2 - 0 | Platense | 15:30 |
| Banfield | 2 - 1 | Colon Santa Fe | 18:00 |
| Belgrano | 0 - 3 | Tigre | 18:00 |
| Real Salt Lake | 1 - 1 | Houston Dynamo | 20:00 |
