| Domingo 05 de Noviembre |
| Qingdao Jonoon | CANC | Inter Miami | 05:00 |
| Chengdu Better City | CANC | Inter Miami | 18:00 |
| Cucuta | 1 - 1 | Millonarios | 16:00 |
| Racing Montevideo | 1 - 1 | La Luz | 11:30 |
| Plaza Colonia | 0 - 2 | Defensor Sporting | 14:00 |
| Peñarol | 0 - 1 | Liverpool | 17:00 |
| União de Leiria | 4 - 3 | Marítimo | 08:00 |
| VfL Wolfsburg | 2 - 2 | Werder Bremen | 08:30 |
| Casa Pia | 0 - 1 | Vizela | 09:30 |
| Moreirense | 1 - 0 | Guimaraes | 09:30 |
| FC Heidenheim | 2 - 0 | VfB Stuttgart | 10:30 |
| Rio Ave | 2 - 0 | Boavista | 12:00 |
| Sporting CP | 3 - 2 | Estrela | 14:30 |
| Utrecht | 1 - 1 | Twente | 05:15 |
| Verona | 1 - 3 | Monza | 05:30 |
| Lyon | 1 - 1 | Metz | 06:00 |
| NEC Nijmegen | 3 - 3 | FC Volendam | 07:30 |
| PEC Zwolle | 2 - 0 | Fortuna Sittard | 07:30 |
| Nantes | 0 - 1 | Reims | 08:00 |
| Cagliari | 2 - 1 | Genoa | 08:00 |
| Nottingham Forest | 2 - 0 | Aston Villa | 08:00 |
| Toulouse | 1 - 2 | LE Havre | 08:00 |
| Strasbourg | 0 - 0 | Clermont Foot | 08:00 |
| Sparta Rotterdam | 1 - 2 | Almere City FC | 09:45 |
| Ajax | 4 - 1 | Heerenveen | 09:45 |
| Monaco | 2 - 0 | Stade Brestois 29 | 10:05 |
| Luton | 1 - 1 | Liverpool | 10:30 |
| AS Roma | 2 - 1 | Lecce | 11:00 |
| Fiorentina | 0 - 1 | Juventus | 13:45 |
| Nice | 2 - 0 | Rennes | 13:45 |
| Hansa Rostock | 0 - 0 | Hertha Berlin | 06:30 |
| Alaves | 1 - 0 | Almeria | 07:00 |
| Cremonese | 3 - 0 | Spezia | 09:15 |
| Valencia | 1 - 0 | Granada CF | 09:15 |
| Parma | 2 - 0 | Sudtirol | 09:15 |
| Villarreal | 2 - 3 | Athletic Club | 11:30 |
| Messina | 0 - 1 | Benevento | 11:30 |
| Real Madrid | 0 - 0 | Rayo Vallecano | 14:00 |
| Groningen | 2 - 2 | Dordrecht | 07:30 |
| Amorebieta | 0 - 1 | Huesca | 09:15 |
| FC Cartagena | 0 - 3 | Leganes | 11:30 |
| Norwich | 1 - 3 | Blackburn | 06:00 |
| Puebla W | 1 - 3 | Tijuana W | 12:00 |
| U.N.A.M. - Pumas | 3 - 0 | Atlas | 12:00 |
| Necaxa | 4 - 0 | Mazatlán | 16:00 |
| Atlético San Luis W | 0 - 1 | Toluca W | 17:00 |
| Santos Laguna | 3 - 1 | Toluca | 18:05 |
| FC Juarez | 0 - 3 | Club Queretaro | 20:06 |
| Tacuary | 1 - 0 | Sportivo Trinidense | 15:00 |
| Club Guarani | 2 - 0 | General Caballero | 17:30 |
| Potencia | 1 - 3 | Rentistas | 07:00 |
| Mushuc Runa SC | 1 - 0 | Tecnico Universitario | 11:30 |
| Cumbayá | 0 - 1 | Orense SC | 14:00 |
| Barcelona SC | 3 - 2 | El Nacional | 17:00 |
| Fortaleza EC | 0 - 2 | Flamengo | 13:00 |
| Cruzeiro | 1 - 2 | Internacional | 13:00 |
| Bragantino | 1 - 0 | Corinthians | 13:00 |
| Coritiba | 0 - 1 | Goias | 15:30 |
| Velez Sarsfield | 1 - 1 | Talleres Cordoba | 13:00 |
| Union Santa Fe | 0 - 0 | Lanus | 13:30 |
| Racing Club | 1 - 1 | Central Cordoba de Santiago | 15:30 |
| Estudiantes L.P. | 2 - 1 | Defensa Y Justicia | 17:30 |
| Newells Old Boys | 0 - 1 | Sarmiento Junin | 18:00 |
| Sporting Kansas City | 2 - 1 | St. Louis City | 16:00 |
| Vancouver Whitecaps | 0 - 1 | Los Angeles FC | 18:30 |
| Temperley | 2 - 1 | Deportivo Maipu | 13:00 |
| Ferro Carril Oeste | 1 - 1 | Almirante Brown | 15:00 |
