| Local | Visita | Hora | |
|---|---|---|---|
| Viernes 03 de Noviembre | |||
| Cerro | 0 - 1 | Wanderers | 16:00 |
| SV Darmstadt 98 | 1 - 2 | VfL BOCHUM | 13:30 |
| FC Porto | 0 - 1 | Estoril | 14:15 |
| Bologna | 1 - 0 | Lazio | 13:45 |
| Paris Saint Germain | 3 - 0 | Montpellier | 14:00 |
| Nimes | 1 - 3 | Epinal | 12:30 |
| Dijon | 2 - 1 | Versailles | 12:30 |
| Las Palmas | 2 - 1 | Atletico Madrid | 14:00 |
| VVV Venlo | 2 - 2 | Jong AZ | 13:00 |
| De Graafschap | 1 - 0 | NAC Breda | 13:00 |
| Espanyol | 2 - 2 | Eibar | 14:00 |
| Leicester | 0 - 1 | Leeds | 14:00 |
| León W | 1 - 1 | Atlas W | 17:00 |
| Necaxa W | 1 - 3 | Tigres UANL W | 17:00 |
| Guadalajara W | 3 - 0 | Pachuca W | 19:00 |
| Puebla | 5 - 4 | Leon | 21:00 |
| Monterrey W | 2 - 1 | América W | 21:00 |
| Juárez W | 0 - 2 | Pumas UNAM W | 21:10 |
| Guairena FC | 0 - 1 | Olimpia | 15:00 |
| Cerro Porteño | 2 - 0 | Sportivo Luqueno | 17:30 |
| Deportivo Cuenca | 0 - 0 | Aucas | 18:00 |
| River Plate | 1 - 2 | Huracan | 18:00 |
