| Local | Visita | Hora | |
|---|---|---|---|
| Jueves 02 de Noviembre | |||
| Arosa | 0 - 3 | Granada CF | 12:00 |
| Chiclana | 0 - 5 | Villarreal | 12:00 |
| UD Logroñés | 0 - 2 | Valencia | 13:00 |
| Deportivo Murcia | 0 - 10 | Alaves | 14:00 |
| Sassuolo | 0 - 0 | Spezia | 11:00 |
| Cambuur | 4 - 1 | MVV | 11:45 |
| Ajax | 2 - 0 | FC Volendam | 13:00 |
| SJC Noordwijk | 1 - 3 | Willem II | 13:00 |
| FC OSS | 0 - 1 | FC Eindhoven | 13:00 |
| NEC Nijmegen | 5 - 3 | Roda | 14:00 |
| Torino | 1 - 2 | Frosinone | 14:00 |
| Sporting CP | 4 - 2 | Farense | 14:15 |
| Atletico Nacional | 3 - 1 | Deportivo Pereira | 14:00 |
| Millonarios | 1 - 0 | Cucuta | 19:00 |
| Celaya | 0 - 0 | Leones Negros UDG | 17:05 |
| Tapatío | 0 - 1 | Dorados | 19:05 |
| Monarcas | 1 - 0 | Tepatitlán | 21:05 |
| Resistencia | 1 - 3 | Tacuary | 15:00 |
| Sportivo Trinidense | 1 - 1 | Libertad | 17:30 |
| Cuiaba | 0 - 2 | Vasco DA Gama | 14:00 |
| Goias | 0 - 2 | Bragantino | 15:00 |
| Sao Paulo | 1 - 0 | Cruzeiro | 17:00 |
