| Miércoles 01 de Noviembre |
| Peña Deportiva | 1 - 5 | Valladolid | 05:00 |
| Badalona | 0 - 0 | Cadiz | 05:00 |
| Atlético Lugones | 0 - 6 | Rayo Vallecano | 05:00 |
| Llerenense | 0 - 2 | Leganes | 05:00 |
| Turégano | 0 - 4 | Celta Vigo | 08:30 |
| Quintanar | 0 - 3 | Sevilla | 08:30 |
| Borussia Dortmund | 1 - 0 | 1899 Hoffenheim | 11:00 |
| SC Freiburg | 1 - 3 | SC Paderborn 07 | 11:00 |
| Holstein Kiel | 3 - 3 | FC Magdeburg | 11:00 |
| SV Sandhausen | 2 - 5 | Bayer Leverkusen | 11:00 |
| Europa Fc | 0 - 2 | Elche | 11:00 |
| Boiro | 0 - 4 | Mallorca | 11:30 |
| Buñol | 0 - 1 | Real Sociedad | 11:30 |
| Tardienta | 0 - 12 | Getafe | 11:30 |
| Águilas | 0 - 1 | Huesca | 12:00 |
| Hernán Cortés | 1 - 12 | Real Betis | 13:30 |
| Hertha Berlin | 3 - 0 | FSV Mainz 05 | 13:45 |
| FC Saarbrucken | 2 - 1 | Bayern Munich | 13:45 |
| FC Viktoria Koln | 0 - 2 | Eintracht Frankfurt | 13:45 |
| Rubí | 1 - 2 | Athletic Club | 14:30 |
| Reggiana | 2 - 1 | Genoa | 08:00 |
| Lecce | 2 - 4 | Parma | 11:00 |
| HHC | 2 - 0 | Heracles | 11:45 |
| Rijnsburgse Boys | 0 - 1 | Groningen | 13:00 |
| AFC Amsterdam | 1 - 0 | PEC Zwolle | 13:00 |
| Sparta Nijkerk | 0 - 1 | Fortuna Sittard | 13:00 |
| Ijsselmeervogels | 0 - 2 | Sparta Rotterdam | 13:00 |
| Den Bosch | 1 - 2 | Excelsior | 14:00 |
| Cagliari | 1 - 2 | Udinese | 14:00 |
| West Ham | 3 - 1 | Arsenal | 13:30 |
| Everton | 3 - 0 | Burnley | 13:45 |
| Chelsea | 2 - 0 | Blackburn | 13:45 |
| Bournemouth | 1 - 2 | Liverpool | 13:45 |
| Ipswich | 1 - 3 | Fulham | 13:45 |
| SC Braga | 1 - 1 | Casa Pia | 14:15 |
| Manchester United | 0 - 3 | Newcastle | 14:15 |
| NEC Nijmegen | VS | Gaddafi | 07:00 |
| Tlaxcala | 0 - 1 | Correcaminos Uat | 17:05 |
| Cancún | 2 - 1 | Mineros de Zacatecas | 19:05 |
| Cruz Azul | 2 - 0 | FC Juarez | 19:00 |
| Atlas | 0 - 2 | Pachuca | 19:00 |
| Atletico San Luis | 0 - 1 | Club America | 21:00 |
| Mazatlán | 3 - 1 | Santos Laguna | 21:00 |
| Club Tijuana | 2 - 0 | Tigres UANL | 21:00 |
| Sportivo Ameliano | 0 - 0 | Club Guarani | 15:00 |
| General Caballero | 0 - 0 | Nacional Asuncion | 17:30 |
| LDU de Quito | 1 - 0 | Universidad Catolica | 18:00 |
| Internacional | 1 - 1 | America Mineiro | 16:00 |
| Corinthians | 1 - 0 | Atletico Paranaense | 16:00 |
| Flamengo | 1 - 2 | Santos | 17:00 |
| Coritiba | 1 - 2 | Gremio | 17:00 |
| Botafogo | 3 - 4 | Palmeiras | 18:30 |
| Atletico-MG | 3 - 1 | Fortaleza EC | 18:30 |
| Defensa Y Justicia | 2 - 2 | Racing Club | 17:00 |
| Columbus Crew | 2 - 0 | Atlanta United FC | 17:30 |
