| Martes 31 de Octubre |
| FC 08 Homburg | 2 - 1 | SpVgg Greuther Furth | 11:00 |
| VfL Wolfsburg | 1 - 0 | RB Leipzig | 11:00 |
| VfB Stuttgart | 1 - 0 | Union Berlin | 11:00 |
| FC St. Pauli | 2 - 1 | FC Schalke 04 | 11:00 |
| Mensajero | 0 - 2 | Espanyol | 13:00 |
| Varea | 0 - 3 | Levante | 13:00 |
| Arminia Bielefeld | 1 - 1 | Hamburger SV | 13:45 |
| FC Kaiserslautern | 3 - 2 | FC Koln | 13:45 |
| Borussia Monchengladbach | 3 - 1 | FC Heidenheim | 13:45 |
| Lorca Deportiva | 0 - 4 | Eibar | 14:00 |
| Cremonese | 2 - 1 | Cittadella | 08:00 |
| Salernitana | 4 - 0 | Sampdoria | 11:00 |
| De Graafschap | 2 - 0 | Emmen | 11:45 |
| Quick Boys | 1 - 0 | NAC Breda | 13:00 |
| Heerenveen | 5 - 1 | VVV Venlo | 13:00 |
| Groene Ster | 0 - 1 | Vitesse | 13:00 |
| Noordwijk | 0 - 1 | ADO Den Haag | 13:00 |
| OJC Rosmalen | 1 - 8 | Almere City FC | 13:00 |
| Koninklijke HFC | 1 - 4 | GO Ahead Eagles | 13:00 |
| Bologna | 2 - 0 | Verona | 14:00 |
| Utrecht | 3 - 2 | Waalwijk | 14:00 |
| Arouca | 0 - 2 | Benfica | 14:15 |
| Alebrijes de Oaxaca | 0 - 3 | Atlante FC | 17:05 |
| Toluca | 0 - 1 | Puebla | 19:00 |
| Club Queretaro | 1 - 2 | Guadalajara Chivas | 19:00 |
| Leon | 1 - 1 | U.N.A.M. - Pumas | 21:00 |
| Monterrey | 3 - 0 | Necaxa | 21:05 |
| Bahia | 1 - 0 | Fluminense | 16:00 |
| Tigre | 1 - 0 | Godoy Cruz | 16:00 |
| Central Cordoba de Santiago | 2 - 0 | Union Santa Fe | 18:00 |
