| Local | Visita | Hora | |
|---|---|---|---|
| Lunes 30 de Octubre | |||
| Miramar | 0 - 0 | Wanderers | 09:00 |
| Oriental | 1 - 0 | Racing Montevideo | 13:00 |
| Uruguay Montevideo | 1 - 2 | Plaza Colonia | 13:00 |
| Boavista | 0 - 2 | Sporting CP | 14:15 |
| Empoli | 0 - 3 | Atalanta | 11:30 |
| Lazio | 1 - 0 | Fiorentina | 13:45 |
| Benevento | 1 - 0 | Potenza | 13:45 |
| Granada CF | 2 - 3 | Villarreal | 14:00 |
| Jong Utrecht | 1 - 1 | MVV | 13:00 |
| Saint Etienne | 2 - 0 | Angers | 13:45 |
| Coventry | 0 - 2 | West Brom | 14:00 |
| Sportivo Luqueno | 2 - 1 | Sportivo Trinidense | 15:00 |
| Libertad | 4 - 1 | Resistencia | 17:30 |
| El Nacional | 2 - 0 | Guayaquil City FC | 18:00 |
| Talleres Cordoba | 0 - 0 | Banfield | 13:00 |
| Lanus | 2 - 0 | Belgrano | 15:30 |
| Sarmiento Junin | 0 - 0 | San Lorenzo | 16:00 |
| Huracan | 0 - 0 | Barracas Central | 18:00 |
| Platense | 0 - 0 | Newells Old Boys | 18:15 |
| America de Cali | 1 - 0 | Millonarios | 19:00 |
| Orlando City SC | 1 - 0 | Nashville SC | 17:00 |
| Seattle Sounders | 2 - 0 | FC Dallas | 19:00 |
| Atletico DE Rafaela | 1 - 0 | Defensores De Belgrano | 18:30 |
