| Domingo 29 de Octubre |
| Albion FC | 0 - 2 | River Plate | 14:00 |
| Rampla Juniors | 2 - 2 | La Luz | 14:00 |
| Progreso | 1 - 1 | Torque | 14:00 |
| SUD America | 0 - 3 | Peñarol | 14:30 |
| Sportivo Barracas | 3 - 2 | Cerro Largo | 14:30 |
| Tacuarembo | 1 - 2 | Fenix | 17:00 |
| Potencia | 0 - 4 | Nacional | 17:15 |
| Defensor Sporting | 0 - 3 | Cerrito | 18:00 |
| Santa Clara | 1 - 1 | Benfica II | 10:30 |
| Eintracht Frankfurt | 3 - 3 | Borussia Dortmund | 09:30 |
| Rio Ave | 3 - 4 | Farense | 10:30 |
| Bayer Leverkusen | 2 - 1 | SC Freiburg | 11:30 |
| Estrela | 1 - 0 | Famalicao | 13:00 |
| Vizela | 0 - 2 | FC Porto | 15:30 |
| Twente | 2 - 1 | Feyenoord | 06:15 |
| Cagliari | 4 - 3 | Frosinone | 06:30 |
| Stade Brestois 29 | 2 - 3 | Paris Saint Germain | 07:00 |
| West Ham | 0 - 1 | Everton | 08:00 |
| PSV Eindhoven | 5 - 2 | Ajax | 08:30 |
| FC Volendam | 3 - 1 | Excelsior | 08:30 |
| Brighton | 1 - 1 | Fulham | 09:00 |
| Monza | 1 - 1 | Udinese | 09:00 |
| Aston Villa | 3 - 1 | Luton | 09:00 |
| Montpellier | 3 - 0 | Toulouse | 09:00 |
| Metz | 0 - 0 | LE Havre | 09:00 |
| Lille | 2 - 0 | Monaco | 09:00 |
| Liverpool | 3 - 0 | Nottingham Forest | 09:00 |
| Manchester United | 0 - 3 | Manchester City | 10:30 |
| Rennes | 1 - 1 | Strasbourg | 11:05 |
| Inter | 1 - 0 | AS Roma | 12:00 |
| Napoli | 2 - 2 | AC Milan | 14:45 |
| Holstein Kiel | 0 - 2 | FC Nurnberg | 07:30 |
| Real Betis | 2 - 1 | Osasuna | 08:00 |
| Crotone | 3 - 3 | Messina | 08:00 |
| Rayo Vallecano | 2 - 2 | Real Sociedad | 10:15 |
| Venezia | 2 - 1 | Pisa | 10:15 |
| Athletic Club | 2 - 2 | Valencia | 12:30 |
| Atletico Madrid | 2 - 1 | Alaves | 15:00 |
| Cambuur | 2 - 1 | Groningen | 06:15 |
| Huesca | 0 - 0 | Albacete | 10:15 |
| Leganes | 1 - 0 | Villarreal II | 12:30 |
| Leones Negros UDG | 2 - 1 | Tlaxcala | 18:00 |
| Toluca | 3 - 1 | Atletico San Luis | 13:00 |
| Santos Laguna | 5 - 1 | FC Juarez | 19:05 |
| Club Tijuana | 2 - 0 | Atlas | 21:06 |
| Olimpia | 0 - 0 | Cerro Porteño | 15:00 |
| Delfin SC | 4 - 0 | Cumbayá | 13:00 |
| Aucas | 4 - 0 | Mushuc Runa SC | 15:30 |
| Orense SC | 2 - 3 | Barcelona SC | 18:00 |
| Atletico Paranaense | 1 - 1 | Sao Paulo | 14:00 |
| Goias | 1 - 1 | Vasco DA Gama | 14:00 |
| Corinthians | 1 - 1 | Santos | 16:30 |
| Internacional | 3 - 4 | Coritiba | 16:30 |
| Botafogo | 0 - 1 | Cuiaba | 18:00 |
| Colon Santa Fe | 1 - 0 | Atletico Tucuman | 12:00 |
| Rosario Central | 3 - 1 | Argentinos JRS | 14:30 |
| Universitario | 2 - 0 | Sport Huancayo | 15:00 |
| Sporting Cristal | 3 - 0 | Alianza Atletico | 15:00 |
| ADT | 0 - 0 | Carlos A. Mannucci | 15:00 |
| Atletico Grau | 0 - 1 | Union Comercio | 15:00 |
| Deportivo Garcilaso | 0 - 1 | Alianza Lima | 15:00 |
| Deportivo Binacional | 1 - 2 | FBC Melgar | 15:00 |
| Gimnasia L.P. | 1 - 2 | River Plate | 15:30 |
| Independiente | 0 - 0 | Arsenal Sarandi | 18:00 |
| Houston Dynamo | 2 - 1 | Real Salt Lake | 17:00 |
| FC Cincinnati | 3 - 0 | New York Red Bulls | 18:00 |
| St. Louis City | 1 - 4 | Sporting Kansas City | 20:00 |
| Almirante Brown | 0 - 2 | Independ. Rivadavia | 16:00 |
| Deportivo Maipu | 1 - 0 | San Martin S.J. | 14:00 |
| Estudiantes de Rio Cuarto | 1 - 0 | Atletico Mitre | 17:00 |
