| Local | Visita | Hora | |
|---|---|---|---|
| Viernes 27 de Octubre | |||
| VfL BOCHUM | 2 - 2 | FSV Mainz 05 | 13:30 |
| Arouca | 0 - 1 | Moreirense | 14:15 |
| Vitesse | 1 - 1 | PEC Zwolle | 13:00 |
| Genoa | 1 - 0 | Salernitana | 13:45 |
| Crystal Palace | 1 - 2 | Tottenham | 14:00 |
| Clermont Foot | 0 - 1 | Nice | 14:00 |
| SpVgg Greuther Furth | 4 - 0 | VfL Osnabruck | 11:30 |
| Cittadella | 1 - 2 | Cremonese | 13:30 |
| Girona | 1 - 0 | Celta Vigo | 14:00 |
| Willem II | 3 - 0 | Jong PSV | 13:00 |
| Emmen | 2 - 1 | Jong AZ | 13:00 |
| Roda | 2 - 1 | Jong Ajax | 13:00 |
| NAC Breda | 1 - 1 | Helmond Sport | 13:00 |
| De Graafschap | 2 - 1 | FC Eindhoven | 13:00 |
| ADO Den Haag | 2 - 2 | VVV Venlo | 13:00 |
| Eibar | 5 - 1 | Valladolid | 14:00 |
| Necaxa | 1 - 0 | U.N.A.M. - Pumas | 20:00 |
| Mazatlán | 3 - 0 | Club Queretaro | 22:00 |
| Tacuary | 3 - 0 | General Caballero | 17:30 |
| Rentistas | 0 - 1 | Bella Vista | 14:00 |
| Libertad | 3 - 0 | Gualaceo SC | 19:00 |
| Durango | 4 - 0 | Colima | 21:00 |
| Huila | 2 - 2 | Santa Fe | 18:00 |
| Deportes Tolima | 2 - 1 | Union Magdalena | 20:10 |
| San Martin Tucuman | 0 - 1 | Deportivo Riestra | 19:30 |
