| Miércoles 25 de Octubre |
| Monterrey | 3 - 1 | Club Tijuana | 20:00 |
| Giugliano | 1 - 2 | Crotone | 11:30 |
| FC Juarez | 3 - 2 | Atletico San Luis | 22:06 |
| Preston | 2 - 2 | Southampton | 13:45 |
| Stoke City | 1 - 0 | Leeds | 14:00 |
| Tepatitlán | 3 - 1 | Alebrijes de Oaxaca | 20:05 |
| Dorados | 1 - 4 | Celaya | 22:05 |
| Resistencia | 0 - 0 | Sportivo Luqueno | 17:30 |
| Feyenoord | 3 - 1 | Lazio | 11:45 |
| Albion FC | 2 - 1 | Rampla Juniors | 14:00 |
| Celtic | 2 - 2 | Atletico Madrid | 14:00 |
| Barcelona | 2 - 1 | Shakhtar Donetsk | 11:45 |
| Antwerp | 1 - 4 | FC Porto | 14:00 |
| Newcastle | 0 - 1 | Borussia Dortmund | 14:00 |
| Paris Saint Germain | 3 - 0 | AC Milan | 14:00 |
| RB Leipzig | 3 - 1 | FK Crvena Zvezda | 14:00 |
| BSC Young Boys | 1 - 3 | Manchester City | 14:00 |
| Fluminense | 5 - 3 | Goias | 17:00 |
| Atletico Paranaense | 3 - 2 | America Mineiro | 17:00 |
| Bragantino | 1 - 2 | Atletico-MG | 17:00 |
| Cruzeiro | 3 - 0 | Bahia | 18:00 |
| Palmeiras | 5 - 0 | Sao Paulo | 18:00 |
| Cuiaba | 0 - 1 | Corinthians | 19:30 |
| Gremio | 3 - 2 | Flamengo | 19:30 |
| Arsenal Sarandi | 1 - 0 | Colon Santa Fe | 14:00 |
| Atletico Tucuman | 1 - 0 | Talleres Cordoba | 16:30 |
| Belgrano | 1 - 1 | Central Cordoba de Santiago | 16:30 |
| River Plate | 3 - 0 | Independiente | 19:00 |
| Bucaramanga | 2 - 3 | La Equidad | 16:00 |
| Deportivo Pereira | 0 - 2 | Junior | 18:10 |
| Millonarios | 1 - 1 | Chico | 20:20 |
| New York Red Bulls | 5 - 2 | Charlotte | 18:30 |
| Sporting Kansas City | 0 - 0 | San Jose Earthquakes | 20:30 |
