| Local | Visita | Hora | |
|---|---|---|---|
| Martes 24 de Octubre | |||
| Danubio | 1 - 1 | Boston River | 14:00 |
| Wanderers | 1 - 2 | Racing Montevideo | 17:30 |
| Leon | 1 - 1 | Atlas | 20:00 |
| Norwich | 1 - 2 | Middlesbrough | 13:45 |
| Swansea | 0 - 1 | Watford | 13:45 |
| Leicester | 1 - 0 | Sunderland | 14:00 |
| West Brom | 2 - 0 | QPR | 14:00 |
| Mineros de Zacatecas | 2 - 2 | Cimarrones | 20:05 |
| Sportivo Trinidense | 2 - 5 | Cerro Porteño | 16:00 |
| Club Guarani | 0 - 1 | Olimpia | 18:30 |
| Galatasaray | 1 - 3 | Bayern Munich | 11:45 |
| Manchester United | 1 - 0 | FC Copenhagen | 14:00 |
| Inter | 2 - 1 | Red Bull Salzburg | 11:45 |
| Benfica | 0 - 1 | Real Sociedad | 14:00 |
| Sevilla | 1 - 2 | Arsenal | 14:00 |
| Lens | 1 - 1 | PSV Eindhoven | 14:00 |
| Union Berlin | 0 - 1 | Napoli | 14:00 |
| SC Braga | 1 - 2 | Real Madrid | 14:00 |
| Barracas Central | 1 - 2 | Gimnasia L.P. | 14:00 |
| Union Santa Fe | 0 - 0 | Defensa Y Justicia | 15:00 |
| Racing Club | 2 - 1 | Boca Juniors | 17:00 |
| Argentinos JRS | 1 - 2 | Huracan | 19:30 |
| Instituto Cordoba | 0 - 0 | Rosario Central | 19:30 |
| Rionegro Aguilas | 3 - 1 | Envigado | 18:00 |
| Deportivo Cali | 2 - 0 | Jaguares | 20:10 |
