| Local | Visita | Hora | |
|---|---|---|---|
| Lunes 23 de Octubre | |||
| Torque | 2 - 3 | Liverpool | 15:00 |
| Nacional | 1 - 3 | Deportivo Maldonado | 18:15 |
| Udinese | 1 - 1 | Lecce | 11:30 |
| Fiorentina | 0 - 2 | Empoli | 13:45 |
| Tottenham | 2 - 0 | Fulham | 14:00 |
| Jong Ajax | 0 - 0 | ADO Den Haag | 13:00 |
| Jong AZ | 3 - 0 | De Graafschap | 13:00 |
| Groningen | 0 - 0 | Emmen | 13:00 |
| Jong PSV | 3 - 4 | FC Eindhoven | 13:00 |
| Palermo | 2 - 2 | Spezia | 13:30 |
| Valencia | 2 - 0 | Cadiz | 14:00 |
| Laval | 0 - 1 | Saint Etienne | 13:45 |
| General Caballero | 0 - 0 | Libertad | 16:00 |
| Sportivo Ameliano | 2 - 1 | Tacuary | 18:30 |
| LDU de Quito | 1 - 0 | Emelec | 12:00 |
| Universidad Catolica | 2 - 2 | Delfin SC | 19:00 |
| Academia Cantolao | 0 - 4 | Atletico Grau | 13:00 |
| Estudiantes L.P. | 2 - 1 | Sarmiento Junin | 17:00 |
| Velez Sarsfield | 0 - 1 | Banfield | 19:00 |
| America de Cali | 1 - 0 | Huila | 20:00 |
