| Local | Visita | Hora | |
|---|---|---|---|
| Miércoles 18 de Octubre | |||
| Quilmes | 1 - 1 | Rampla Juniors | 18:00 |
| Sportivo Barracas | 1 - 1 | Rentistas | 18:30 |
| Liverpool | 2 - 0 | Defensor Sporting | 10:00 |
| Plaza Colonia | 1 - 0 | Wanderers | 12:30 |
| Cerro Largo | 1 - 3 | La Luz | 15:00 |
| Torque | 2 - 3 | Peñarol | 17:30 |
| Nacional Asuncion | 4 - 0 | Club Guarani | 16:00 |
| Tacuary | 1 - 3 | Guairena FC | 18:30 |
| Gremio | 1 - 2 | Atletico Paranaense | 17:00 |
| Coritiba | 0 - 3 | Cuiaba | 18:00 |
| America Mineiro | 1 - 2 | Botafogo | 18:00 |
| Goias | 2 - 0 | Sao Paulo | 19:30 |
| Vasco DA Gama | 1 - 0 | Fortaleza EC | 19:30 |
| Bahia | 1 - 0 | Internacional | 19:30 |
| Inter Miami | 2 - 2 | Charlotte | 19:00 |
| 9 de Octubre | 3 - 1 | Guayaquil | 15:30 |
| Chacaritas | 1 - 0 | UT Cotopaxi | 15:30 |
| Vargas Torres | 0 - 1 | America de Quito | 15:30 |
| Macara | 1 - 3 | Manta FC | 18:30 |
| Cuniburo | 1 - 1 | Imbabura | 18:30 |
| Platense | 2 - 1 | Estudiantes L.P. | 17:00 |
| Independiente | 3 - 0 | Barracas Central | 19:00 |
| Millonarios | 1 - 1 | Union Magdalena | 20:00 |
