| Local | Visita | Hora | |
|---|---|---|---|
| Miércoles 11 de Octubre | |||
| Reusrath | 0 - 15 | FC Koln | 11:00 |
| Bahrain | VS | Philippines | 19:00 |
| Wales | 4 - 0 | Gibraltar | 13:45 |
| Basáñez | 0 - 1 | Cerrito | 16:00 |
| Nacional Asuncion | 2 - 0 | Martin Ledesma | 17:30 |
| Juventud de Colonia | 0 - 5 | Albion FC | 18:30 |
| Chaco For Ever | 1 - 1 | Defensa Y Justicia | 19:10 |
| Marignane | 1 - 1 | Nimes | 14:00 |
| Dijon | 4 - 1 | Epinal | 14:00 |
| Mazatlán W | 2 - 2 | Santos Laguna W | 20:06 |
| Tapatío | 2 - 4 | Leones Negros UDG | 20:05 |
| Deportivo Cali | 2 - 0 | Deportes Tolima | 18:15 |
| Manta FC | 1 - 2 | UT Cotopaxi | 15:00 |
| Guayaquil | 1 - 3 | Cuniburo | 15:00 |
| America de Quito | 1 - 0 | 9 de Octubre | 16:30 |
| Macara | 1 - 2 | Chacaritas | 19:00 |
| Deportivo Pereira | 0 - 0 | Rionegro Aguilas | 20:30 |
