| Viernes 06 de Octubre |
| Torque | 1 - 0 | La Luz | 18:00 |
| Santa Clara | 2 - 0 | Academico Viseu | 12:00 |
| Borussia Monchengladbach | 2 - 2 | FSV Mainz 05 | 13:30 |
| Empoli | 0 - 0 | Udinese | 11:30 |
| FC Volendam | 1 - 0 | Utrecht | 13:00 |
| Lecce | 1 - 1 | Sassuolo | 13:45 |
| Strasbourg | 1 - 2 | Nantes | 14:00 |
| Moreirense | 1 - 1 | Boavista | 14:15 |
| Nimes | 1 - 0 | Niort | 12:30 |
| Dijon | 0 - 0 | Marignane | 12:30 |
| Roda | 3 - 1 | Jong AZ | 13:00 |
| NAC Breda | 3 - 2 | Groningen | 13:00 |
| Willem II | 4 - 2 | De Graafschap | 13:00 |
| Jong Ajax | 3 - 0 | VVV Venlo | 13:00 |
| Emmen | 2 - 0 | Telstar | 13:00 |
| Den Bosch | 0 - 1 | FC Eindhoven | 13:00 |
| Dordrecht | 5 - 2 | Cambuur | 13:00 |
| ADO Den Haag | 2 - 1 | FC OSS | 13:00 |
| Jong PSV | 2 - 3 | MVV | 13:00 |
| Athletic Club | 3 - 0 | Almeria | 14:00 |
| Albacete | 0 - 2 | Levante | 14:00 |
| Birmingham | 3 - 1 | West Brom | 14:00 |
| Correcaminos Uat | 0 - 1 | Celaya | 18:00 |
| Mazatlán | 1 - 2 | Club America | 22:00 |
| Cruz Azul W | 3 - 1 | Atlético San Luis W | 16:45 |
| General Caballero | 1 - 1 | Cerro Porteño | 17:30 |
| Atlas W | 3 - 1 | Mazatlán W | 20:00 |
| Deportivo Cuenca | 2 - 3 | Universidad Catolica | 19:00 |
| Union La Calera | 2 - 4 | Huachipato | 17:00 |
| Rosario Central | 1 - 0 | Huracan | 18:30 |
| Jaguares | 0 - 1 | Deportes Tolima | 18:00 |
| Junior | 3 - 2 | Deportivo Cali | 20:10 |
| Guillermo Brown | 2 - 0 | Alvarado | 13:30 |
| Nueva Chicago | 2 - 1 | Defensores De Belgrano | 15:00 |
| All Boys | 1 - 2 | Estudiantes de Rio Cuarto | 19:30 |
