| Local | Visita | Hora | |
|---|---|---|---|
| Jueves 05 de Octubre | |||
| AEK Athens FC | 1 - 1 | Ajax | 11:45 |
| Marseille | 2 - 2 | Brighton | 11:45 |
| SC Freiburg | 1 - 2 | West Ham | 11:45 |
| Sporting CP | 1 - 2 | Atalanta | 11:45 |
| Real Betis | 2 - 1 | Sparta Praha | 11:45 |
| Molde | 1 - 2 | Bayer Leverkusen | 14:00 |
| AS Roma | 4 - 0 | Servette FC | 14:00 |
| Villarreal | 1 - 0 | Rennes | 14:00 |
| Toulouse | 1 - 0 | Lask Linz | 14:00 |
| Liverpool | 2 - 0 | Union St. Gilloise | 14:00 |
| Racing Montevideo | 1 - 2 | Nacional | 18:00 |
| Independiente Medellin | 1 - 2 | Cucuta | 18:00 |
| Alianza Petrolera | 1 - 2 | Millonarios | 20:30 |
| KI Klaksvik | 0 - 0 | Lille | 11:45 |
| PAOK | 2 - 1 | Eintracht Frankfurt | 14:00 |
| Fiorentina | 2 - 2 | Ferencvarosi TC | 14:00 |
| Aston Villa | 1 - 0 | Zrinjski | 14:00 |
| AZ Alkmaar | 1 - 0 | Legia Warszawa | 14:00 |
| Mirandes | 1 - 3 | Eibar | 12:00 |
| FC Cartagena | 0 - 2 | Espanyol | 14:30 |
| Toluca W | 3 - 0 | Puebla W | 18:00 |
| Tapatío | 1 - 2 | Cimarrones | 18:05 |
| Palmeiras | 1 - 1 | Boca Juniors | 19:30 |
| Cancún | 2 - 0 | Leones Negros UDG | 20:05 |
| Tepatitlán | 4 - 0 | CA La Paz | 22:05 |
| Cuniburo | 2 - 1 | Macara | 19:00 |
