| Local | Visita | Hora | |
|---|---|---|---|
| Martes 03 de Octubre | |||
| Luton | 1 - 2 | Burnley | 13:30 |
| Bordeaux | 1 - 1 | Caen | 11:45 |
| Willem II | 2 - 1 | FC OSS | 13:00 |
| Levante | 1 - 1 | Villarreal II | 12:00 |
| Verl | 3 - 1 | Arminia Bielefeld | 12:00 |
| West Brom | 1 - 0 | Sheffield Wednesday | 14:00 |
| Stoke City | 0 - 1 | Southampton | 14:00 |
| Fortaleza EC | 2 - 0 | Corinthians | 19:30 |
| Puebla | 1 - 1 | Monterrey | 20:00 |
| Club America | 4 - 0 | Pachuca | 22:00 |
| Dorados | 3 - 1 | Tlaxcala | 22:05 |
| Union Berlin | 2 - 3 | SC Braga | 11:45 |
| Napoli | 2 - 3 | Real Madrid | 14:00 |
| Red Bull Salzburg | 0 - 2 | Real Sociedad | 11:45 |
| Inter | 1 - 0 | Benfica | 14:00 |
| FC Copenhagen | 1 - 2 | Bayern Munich | 14:00 |
| Manchester United | 2 - 3 | Galatasaray | 14:00 |
| Lens | 2 - 1 | Arsenal | 14:00 |
| PSV Eindhoven | 2 - 2 | Sevilla | 14:00 |
| Chacaritas | 4 - 0 | Guayaquil | 19:00 |
| Sporting Cristal | 2 - 0 | Sport Huancayo | 15:00 |
| Sport Boys | 2 - 1 | Cusco | 15:15 |
| FBC Melgar | 2 - 1 | Carlos A. Mannucci | 18:00 |
| Deportivo Binacional | 1 - 2 | Alianza Lima | 20:30 |
