| Lunes 02 de Octubre |
| MVV | 0 - 1 | FC Eindhoven | 13:00 |
| Sassuolo | 0 - 1 | Monza | 11:30 |
| Torino | 0 - 0 | Verona | 11:30 |
| Fiorentina | 3 - 0 | Cagliari | 13:45 |
| Fulham | 0 - 2 | Chelsea | 14:00 |
| Gil Vicente | 2 - 0 | Casa Pia | 14:15 |
| Jong Utrecht | 1 - 1 | NAC Breda | 13:00 |
| Las Palmas | 2 - 1 | Celta Vigo | 14:00 |
| Espanyol | 3 - 0 | Racing Ferrol | 14:00 |
| Ajaccio | 2 - 0 | Bastia | 13:45 |
| Toluca | 1 - 1 | Guadalajara Chivas | 18:20 |
| Sportivo Luqueno | 1 - 0 | Guairena FC | 16:00 |
| Olimpia | 0 - 0 | Resistencia | 18:30 |
| Atlético San Luis W | 0 - 2 | Tijuana W | 20:00 |
| Tigres UANL W | 3 - 0 | Pumas UNAM W | 20:00 |
| Atlas W | 2 - 1 | Puebla W | 20:06 |
| Santos Laguna W | 2 - 2 | Toluca W | 22:10 |
| Universidad de Chile | 2 - 0 | A. Italiano | 17:00 |
| Botafogo | 1 - 1 | Goias | 18:00 |
| Barracas Central | 1 - 1 | Sarmiento Junin | 16:30 |
| Instituto Cordoba | 1 - 1 | Godoy Cruz | 16:30 |
| Atletico Tucuman | 0 - 0 | Central Cordoba de Santiago | 19:00 |
| Platense | 0 - 0 | Argentinos JRS | 19:00 |
| Universitario | 3 - 0 | UTC | 20:30 |
| Huila | 1 - 1 | La Equidad | 20:10 |
| Brown DE Adrogue | 1 - 2 | Chacarita Juniors | 13:00 |
| Villa Dalmine | 2 - 3 | Deportivo Maipu | 13:30 |
| Deportivo Riestra | 3 - 0 | Aldosivi | 13:30 |
| Deportivo Moron | 0 - 0 | San Martin Tucuman | 19:10 |
