| Local | Visita | Hora | |
|---|---|---|---|
| Jueves 28 de Septiembre | |||
| AZ Alkmaar | 1 - 1 | Heracles | 13:00 |
| Casa Pia | 2 - 1 | Nacional | 14:15 |
| Club Guarani | 2 - 0 | Guairena FC | 18:30 |
| Cucuta | 0 - 1 | Independiente Medellin | 17:00 |
| Millonarios | 2 - 0 | Alianza Petrolera | 19:10 |
| Monza | 0 - 0 | Bologna | 11:30 |
| Frosinone | 1 - 1 | Fiorentina | 11:30 |
| Genoa | 4 - 1 | AS Roma | 13:45 |
| Celta Vigo | 1 - 1 | Alaves | 12:00 |
| Granada CF | 1 - 1 | Real Betis | 12:00 |
| Estrela | 2 - 4 | SC Braga | 14:15 |
| Osasuna | 0 - 2 | Atletico Madrid | 14:30 |
| Atlas | 2 - 3 | Puebla | 21:00 |
| Boca Juniors | 0 - 0 | Palmeiras | 19:30 |
| Manta FC | 1 - 0 | Chacaritas | 19:00 |
| Union Comercio | 2 - 2 | Deportivo Binacional | 13:00 |
| Cesar Vallejo | 0 - 1 | Universitario | 18:00 |
| Alianza Lima | 0 - 0 | FBC Melgar | 20:30 |
