| Domingo 24 de Septiembre |
| Ribeirão | 0 - 3 | Santa Clara | 09:00 |
| 1º Dezembro | 1 - 0 | Paços de Ferreira | 09:00 |
| Empoli | 0 - 1 | Inter | 05:30 |
| Atalanta | 2 - 0 | Cagliari | 08:00 |
| Udinese | 0 - 2 | Fiorentina | 08:00 |
| Bayer Leverkusen | 4 - 1 | FC Heidenheim | 08:30 |
| Eintracht Frankfurt | 0 - 0 | SC Freiburg | 10:30 |
| Bologna | 0 - 0 | Napoli | 11:00 |
| Crotone | 1 - 0 | Sorrento | 13:45 |
| Torino | 1 - 1 | AS Roma | 13:45 |
| Sparta Rotterdam | 1 - 0 | Vitesse | 05:15 |
| Metz | 0 - 1 | Strasbourg | 06:00 |
| Real Sociedad | 4 - 3 | Getafe | 07:00 |
| LE Havre | 2 - 1 | Clermont Foot | 08:00 |
| Lens | 2 - 1 | Toulouse | 08:00 |
| Liverpool | 3 - 1 | West Ham | 08:00 |
| Chelsea | 0 - 1 | Aston Villa | 08:00 |
| Brighton | 3 - 1 | Bournemouth | 08:00 |
| Arsenal | 2 - 2 | Tottenham | 08:00 |
| Parma | 1 - 1 | Sampdoria | 09:15 |
| Rayo Vallecano | 1 - 1 | Villarreal | 09:15 |
| Chaves | 2 - 2 | Estrela | 09:30 |
| PEC Zwolle | 0 - 3 | AZ Alkmaar | 09:45 |
| Waalwijk | 1 - 0 | Twente | 09:45 |
| Montpellier | 0 - 0 | Rennes | 10:05 |
| Sheffield Utd | 0 - 8 | Newcastle | 10:30 |
| Las Palmas | 1 - 0 | Granada CF | 11:30 |
| Real Betis | 1 - 1 | Cadiz | 11:30 |
| Portimonense | 1 - 3 | Benfica | 12:00 |
| Paris Saint Germain | 4 - 0 | Marseille | 13:45 |
| Atletico Madrid | 3 - 1 | Real Madrid | 14:00 |
| SC Braga | 4 - 1 | Boavista | 14:30 |
| Holstein Kiel | 2 - 3 | Hertha Berlin | 06:30 |
| MVV | 1 - 2 | De Graafschap | 07:30 |
| Oviedo | 0 - 1 | Valladolid | 09:15 |
| Mirandes | 1 - 3 | Leganes | 11:30 |
| Sao Paulo | 1 - 1 | Flamengo | 14:00 |
| Toluca | 1 - 1 | Club America | 13:00 |
| Cruz Azul | 1 - 3 | Club Queretaro | 17:00 |
| Tapatío | 2 - 2 | Tepatitlán | 19:00 |
| Santos Laguna | 2 - 5 | Necaxa | 21:05 |
| Club Guarani | 2 - 1 | Sportivo Luqueno | 16:30 |
| Sportivo Ameliano | 0 - 3 | Sportivo Trinidense | 19:00 |
| Cumbayá | 1 - 1 | Aucas | 14:00 |
| Delfin SC | 1 - 0 | Guayaquil City FC | 16:30 |
| Deportivo Cuenca | 1 - 2 | Barcelona SC | 19:00 |
| Deportes Copiapo | 3 - 1 | Universidad de Chile | 13:00 |
| U. Catolica | 1 - 0 | Magallanes | 15:30 |
| A. Italiano | 2 - 1 | Union La Calera | 18:00 |
| Independiente | 0 - 0 | Instituto Cordoba | 13:00 |
| Newells Old Boys | 0 - 1 | Estudiantes L.P. | 15:45 |
| Tigre | 0 - 0 | San Lorenzo | 17:00 |
| Banfield | 1 - 1 | River Plate | 19:00 |
| ADT | 1 - 0 | Alianza Atletico | 13:00 |
| Sport Boys | 0 - 2 | Cesar Vallejo | 15:00 |
| FBC Melgar | 3 - 1 | Union Comercio | 15:15 |
| Carlos A. Mannucci | 1 - 2 | Alianza Lima | 17:15 |
| Deportivo Garcilaso | 0 - 3 | Cienciano | 19:30 |
| Santa Fe | 1 - 0 | Deportivo Pereira | 18:10 |
| Junior | 0 - 1 | Deportes Tolima | 20:20 |
| New York City FC | 3 - 0 | Toronto FC | 12:00 |
| Orlando City SC | 1 - 1 | Inter Miami | 18:30 |
| Austin | 3 - 3 | Los Angeles Galaxy | 20:30 |
| Atletico Mitre | 3 - 0 | Brown DE Adrogue | 09:00 |
| Atlanta | 1 - 1 | Ferro Carril Oeste | 11:50 |
| Tristan Suarez | 1 - 2 | Gimnasia Jujuy | 13:00 |
| Racing Cordoba | 1 - 0 | Deportivo Riestra | 15:00 |
| Aldosivi | 1 - 1 | Villa Dalmine | 17:00 |
| Almagro | 1 - 1 | Alvarado | 13:30 |
| Guillermo Brown | 1 - 0 | San Martin S.J. | 13:30 |
| Nueva Chicago | 0 - 0 | Deportivo Moron | 13:50 |
| Estudiantes de Rio Cuarto | 1 - 0 | Defensores De Belgrano | 16:00 |
