| Sábado 23 de Septiembre |
| Fabril Barreiro | 1 - 3 | Marítimo | 05:00 |
| AC Milan | 1 - 0 | Verona | 08:00 |
| FC Augsburg | 2 - 1 | FSV Mainz 05 | 08:30 |
| Borussia Monchengladbach | 0 - 1 | RB Leipzig | 08:30 |
| Union Berlin | 0 - 2 | 1899 Hoffenheim | 08:30 |
| Borussia Dortmund | 1 - 0 | VfL Wolfsburg | 08:30 |
| Bayern Munich | 7 - 0 | VfL BOCHUM | 08:30 |
| Sassuolo | 4 - 2 | Juventus | 11:00 |
| Werder Bremen | 2 - 1 | FC Koln | 11:30 |
| Lazio | 1 - 1 | Monza | 13:45 |
| Cremonese | 2 - 2 | Ascoli | 07:00 |
| Girona | 5 - 3 | Mallorca | 07:00 |
| Brescia | 0 - 0 | Venezia | 07:00 |
| Luton | 1 - 1 | Wolves | 09:00 |
| Crystal Palace | 0 - 0 | Fulham | 09:00 |
| Manchester City | 2 - 0 | Nottingham Forest | 09:00 |
| Spezia | 1 - 2 | Reggiana | 09:15 |
| Osasuna | 0 - 0 | Sevilla | 09:15 |
| Estoril | 2 - 2 | Vizela | 09:30 |
| Moreirense | 1 - 0 | Farense | 09:30 |
| FC Volendam | 2 - 2 | Heracles | 09:30 |
| Nantes | 5 - 3 | Lorient | 10:00 |
| Emmen | 4 - 0 | Kickers Luzern | 11:00 |
| Brentford | 1 - 3 | Everton | 11:30 |
| Barcelona | 3 - 2 | Celta Vigo | 11:30 |
| NEC Nijmegen | 3 - 0 | Utrecht | 11:45 |
| Casa Pia | 0 - 0 | Guimaraes | 12:00 |
| Almere City FC | 0 - 4 | PSV Eindhoven | 13:00 |
| Stade Brestois 29 | 1 - 0 | Lyon | 14:00 |
| Heerenveen | 0 - 3 | Excelsior | 14:00 |
| Burnley | 0 - 1 | Manchester United | 14:00 |
| Almeria | 2 - 2 | Valencia | 14:00 |
| FC Porto | 2 - 1 | Gil Vicente | 14:30 |
| SpVgg Greuther Furth | 4 - 3 | Karlsruher SC | 06:00 |
| Estac Troyes | 1 - 2 | Auxerre | 08:00 |
| Levante | 2 - 0 | Eldense | 09:15 |
| Burgos | 4 - 0 | Elche | 11:30 |
| Concarneau | 0 - 1 | Saint Etienne | 12:00 |
| Angers | 2 - 0 | Bastia | 12:00 |
| Ajaccio | 2 - 1 | Paris FC | 12:00 |
| FC St. Pauli | 3 - 1 | FC Schalke 04 | 13:30 |
| Alcorcon | 0 - 2 | Huesca | 14:00 |
| Leicester | 1 - 0 | Bristol City | 09:00 |
| Leeds | 3 - 0 | Watford | 09:00 |
| West Brom | 0 - 0 | Millwall | 09:00 |
| Plymouth | 6 - 2 | Norwich | 09:00 |
| Middlesbrough | 2 - 1 | Southampton | 09:00 |
| Guadalajara Chivas | 0 - 0 | Pachuca | 20:00 |
| Leon | 1 - 0 | Club Tijuana | 20:00 |
| Tigres UANL | 3 - 0 | Monterrey | 22:05 |
| Tacuary | 0 - 0 | Olimpia | 16:30 |
| Nacional Asuncion | 2 - 3 | Libertad | 19:00 |
| Universidad Catolica | 0 - 0 | Gualaceo SC | 13:00 |
| Emelec | 3 - 1 | Mushuc Runa SC | 15:30 |
| Tecnico Universitario | 2 - 2 | Independiente del Valle | 18:00 |
| Palestino | 2 - 1 | Union Espanola | 10:30 |
| Curico Unido | 0 - 3 | Nublense | 13:00 |
| Colo Colo | 6 - 0 | Cobresal | 15:30 |
| Everton de Vina | 1 - 2 | Huachipato | 18:00 |
| Atletico-MG | 1 - 0 | Cuiaba | 19:00 |
| Gimnasia L.P. | 2 - 1 | Rosario Central | 14:00 |
| Boca Juniors | 1 - 1 | Lanus | 16:30 |
| Defensa Y Justicia | 2 - 1 | Central Cordoba de Santiago | 19:00 |
| Huracan | 3 - 0 | Velez Sarsfield | 19:00 |
| Deportivo Binacional | 1 - 0 | Academia Cantolao | 15:00 |
| Chico | 0 - 1 | Rionegro Aguilas | 16:00 |
| America de Cali | 4 - 1 | Atletico Nacional | 20:20 |
| FC Cincinnati | 3 - 0 | Charlotte | 18:30 |
| Atlanta United FC | 4 - 1 | Montreal Impact | 18:30 |
| Philadelphia Union | 0 - 0 | Los Angeles FC | 18:30 |
| DC United | 3 - 5 | New York Red Bulls | 18:30 |
| Sporting Kansas City | 2 - 1 | Houston Dynamo | 19:30 |
| FC Dallas | 1 - 1 | Columbus Crew | 19:30 |
| Chicago Fire | 2 - 2 | New England Revolution | 19:30 |
| Minnesota Stars FC | 1 - 2 | St. Louis City | 19:30 |
| Real Salt Lake | 2 - 1 | Vancouver Whitecaps | 20:30 |
| San Jose Earthquakes | 1 - 1 | Nashville SC | 21:30 |
| Portland Timbers | 3 - 2 | Colorado Rapids | 21:30 |
| Chacarita Juniors | 2 - 2 | Quilmes | 14:10 |
| Chaco For Ever | 2 - 1 | CA Estudiantes | 15:30 |
| Agropecuario | 3 - 0 | Flandria | 13:00 |
| San Telmo | 3 - 2 | Gimnasia M. | 13:30 |
| Temperley | 3 - 1 | Patronato | 13:35 |
| San Martin Tucuman | 1 - 1 | Club Atlético Güemes | 16:00 |
