| Miércoles 20 de Septiembre |
| Club Sp. San Lorenzo | 1 - 2 | Libertad | 16:00 |
| Central Espanol | 2 - 1 | Quilmes | 19:00 |
| Club Queretaro | 1 - 2 | Club America | 21:06 |
| Lille | 2 - 0 | Olimpija | 09:30 |
| Watford | 2 - 2 | West Brom | 13:45 |
| Hull City | 0 - 0 | Leeds | 13:45 |
| Norwich | 0 - 2 | Leicester | 14:00 |
| Olimpia | 4 - 0 | Sportivo Ameliano | 18:30 |
| Bayern Munich | 4 - 3 | Manchester United | 14:00 |
| Tlaxcala | 2 - 3 | Monarcas | 18:05 |
| Correcaminos Uat | 1 - 2 | Leones Negros UDG | 20:05 |
| Real Madrid | 1 - 0 | Union Berlin | 11:45 |
| SC Braga | 1 - 2 | Napoli | 14:00 |
| Arsenal | 4 - 0 | PSV Eindhoven | 14:00 |
| Sevilla | 1 - 1 | Lens | 14:00 |
| Real Sociedad | 1 - 1 | Inter | 14:00 |
| Benfica | 0 - 2 | Red Bull Salzburg | 14:00 |
| Goias | 0 - 0 | Flamengo | 17:00 |
| Sao Paulo | 1 - 2 | Fortaleza EC | 19:30 |
| Fluminense | 1 - 0 | Cruzeiro | 19:30 |
| Chacaritas | 1 - 2 | Imbabura | 15:00 |
| 9 de Octubre | 1 - 2 | Cuniburo | 15:00 |
| UT Cotopaxi | 2 - 0 | Guayaquil | 19:00 |
| Barracas Central | 1 - 0 | Banfield | 14:00 |
| Defensa Y Justicia | 2 - 0 | Tigre | 14:00 |
| Velez Sarsfield | 2 - 1 | Arsenal Sarandi | 16:30 |
| Estudiantes L.P. | 0 - 0 | San Lorenzo | 16:30 |
| Instituto Cordoba | 3 - 1 | Colon Santa Fe | 19:00 |
| Racing Club | 2 - 1 | Newells Old Boys | 19:00 |
| Union Comercio | 0 - 0 | Carlos A. Mannucci | 13:00 |
| UTC | 5 - 1 | Deportivo Municipal | 15:30 |
| Cienciano | 2 - 2 | ADT | 18:30 |
| Universitario | 3 - 0 | Sport Boys | 20:30 |
| Chico | 2 - 1 | Junior | 16:00 |
| Rionegro Aguilas | 2 - 2 | America de Cali | 18:10 |
| Atletico Nacional | 3 - 0 | Santa Fe | 20:20 |
| DC United | 1 - 1 | Atlanta United FC | 18:30 |
| Columbus Crew | 3 - 0 | Chicago Fire | 18:30 |
| Charlotte | 2 - 2 | Philadelphia Union | 18:30 |
| New York Red Bulls | 1 - 1 | Austin | 18:30 |
| Montreal Impact | 1 - 1 | FC Cincinnati | 18:30 |
| Inter Miami | 4 - 0 | Toronto FC | 18:30 |
| New York City FC | 2 - 0 | Orlando City SC | 18:30 |
| Sporting Kansas City | 0 - 3 | Nashville SC | 19:30 |
| Houston Dynamo | 4 - 1 | Vancouver Whitecaps | 19:30 |
| St. Louis City | 0 - 0 | Los Angeles FC | 19:30 |
| Real Salt Lake | 1 - 3 | FC Dallas | 20:30 |
| Colorado Rapids | 1 - 2 | Seattle Sounders | 20:30 |
| Portland Timbers | 2 - 1 | San Jose Earthquakes | 21:30 |
| Los Angeles Galaxy | 4 - 3 | Minnesota Stars FC | 21:30 |
| Almagro | 0 - 3 | San Martin S.J. | 13:30 |
