| Martes 19 de Septiembre |
| Nacional Asuncion | 0 - 0 | Sportivo Luqueno | 16:00 |
| Tacuary | 1 - 2 | Sportivo Trinidense | 18:30 |
| AC Milan | 0 - 0 | Newcastle | 11:45 |
| Paris Saint Germain | 2 - 0 | Borussia Dortmund | 14:00 |
| BSC Young Boys | 1 - 3 | RB Leipzig | 11:45 |
| Southampton | 0 - 1 | Ipswich | 13:45 |
| Manchester City | 3 - 1 | FK Crvena Zvezda | 14:00 |
| Lazio | 1 - 1 | Atletico Madrid | 14:00 |
| Feyenoord | 2 - 0 | Celtic | 14:00 |
| Shakhtar Donetsk | 1 - 3 | FC Porto | 14:00 |
| Barcelona | 5 - 0 | Antwerp | 14:00 |
| Celaya | 2 - 3 | Mineros de Zacatecas | 18:05 |
| Cancún | 5 - 2 | Cimarrones | 20:05 |
| Alebrijes de Oaxaca | 2 - 2 | CA La Paz | 22:05 |
| America Mineiro | 0 - 2 | Bragantino | 19:30 |
| America de Quito | 5 - 1 | Manta FC | 19:00 |
| Central Cordoba de Santiago | 0 - 3 | Boca Juniors | 16:45 |
| Huracan | 2 - 0 | Gimnasia L.P. | 19:00 |
| Rosario Central | 1 - 1 | Independiente | 19:00 |
| Alianza Atletico | 1 - 0 | Deportivo Binacional | 13:00 |
| Academia Cantolao | 0 - 1 | FBC Melgar | 15:20 |
| La Equidad | 1 - 1 | Deportivo Cali | 20:20 |
