| Local | Visita | Hora | |
|---|---|---|---|
| Lunes 18 de Septiembre | |||
| Salernitana | 0 - 3 | Torino | 11:30 |
| Verona | 0 - 0 | Bologna | 13:45 |
| Emmen | 2 - 0 | Jong Utrecht | 13:00 |
| De Graafschap | 2 - 1 | Helmond Sport | 13:00 |
| FC Eindhoven | 1 - 1 | ADO Den Haag | 13:00 |
| Groningen | 4 - 0 | Jong PSV | 13:00 |
| Sampdoria | 1 - 2 | Cittadella | 13:30 |
| Nottingham Forest | 1 - 1 | Burnley | 13:45 |
| Granada CF | 2 - 4 | Girona | 14:00 |
| Boavista | 4 - 1 | Chaves | 14:15 |
| Nancy | 3 - 0 | Dijon | 11:15 |
| Guingamp | 3 - 0 | Ajaccio | 13:45 |
| Pachuca | 3 - 2 | Santos Laguna | 22:00 |
| Corinthians | 4 - 4 | Gremio | 19:00 |
| Gualaceo SC | 0 - 3 | Cumbayá | 19:00 |
| Bahia | 1 - 2 | Santos | 18:00 |
| Lanus | 0 - 0 | Sarmiento Junin | 18:00 |
| Envigado | 1 - 0 | Jaguares | 16:00 |
| Union Magdalena | 1 - 1 | Once Caldas | 16:30 |
| Bucaramanga | 1 - 1 | Deportivo Pereira | 18:40 |
| Independiente Medellin | 1 - 1 | Millonarios | 20:50 |
| Ferro Carril Oeste | 2 - 1 | Tristan Suarez | 19:10 |
