| Sábado 02 de Septiembre |
| Bayer Leverkusen | 5 - 1 | SV Darmstadt 98 | 08:30 |
| VfB Stuttgart | 5 - 0 | SC Freiburg | 08:30 |
| FC Augsburg | 2 - 2 | VfL BOCHUM | 08:30 |
| Werder Bremen | 4 - 0 | FSV Mainz 05 | 08:30 |
| 1899 Hoffenheim | 3 - 1 | VfL Wolfsburg | 08:30 |
| Danubio | 2 - 0 | Cerro Largo | 10:30 |
| Ascona | 0 - 3 | Emmen | 11:00 |
| Udinese | 0 - 0 | Frosinone | 11:30 |
| Borussia Monchengladbach | 1 - 2 | Bayern Munich | 11:30 |
| Bologna | 2 - 1 | Cagliari | 11:30 |
| Boston River | 0 - 1 | Peñarol | 13:30 |
| Napoli | 1 - 2 | Lazio | 13:45 |
| Atalanta | 3 - 0 | Monza | 13:45 |
| La Luz | 1 - 1 | Defensor Sporting | 18:00 |
| Sheffield Utd | 2 - 2 | Everton | 06:30 |
| Real Sociedad | 5 - 3 | Granada CF | 07:00 |
| Feirense | 0 - 2 | Santa Clara | 08:00 |
| Burnley | 2 - 5 | Tottenham | 09:00 |
| Brentford | 2 - 2 | Bournemouth | 09:00 |
| Manchester City | 5 - 1 | Fulham | 09:00 |
| Chelsea | 0 - 1 | Nottingham Forest | 09:00 |
| Real Madrid | 2 - 1 | Getafe | 09:15 |
| Casa Pia | 1 - 1 | Rio Ave | 09:30 |
| Almere City FC | 1 - 2 | PEC Zwolle | 09:30 |
| Stade Brestois 29 | 0 - 0 | Rennes | 10:00 |
| Brighton | 3 - 1 | Newcastle | 11:30 |
| Parma | 0 - 0 | Reggiana | 11:30 |
| Alaves | 1 - 0 | Valencia | 11:30 |
| Levante | 1 - 1 | Oviedo | 11:30 |
| GO Ahead Eagles | 3 - 2 | Heerenveen | 11:45 |
| Marítimo | 2 - 0 | Paços de Ferreira | 12:00 |
| Famalicao | 1 - 0 | Farense | 12:00 |
| Portimonense | 1 - 1 | Estrela | 12:00 |
| Waalwijk | 0 - 4 | PSV Eindhoven | 13:00 |
| Heracles | 3 - 1 | Excelsior | 14:00 |
| Real Betis | 1 - 0 | Rayo Vallecano | 14:00 |
| Elche | 1 - 1 | Racing Santander | 14:00 |
| Monaco | 3 - 0 | Lens | 14:00 |
| Benfica | 4 - 0 | Guimaraes | 14:30 |
| SV Wehen | 1 - 1 | FC Schalke 04 | 06:00 |
| FC Magdeburg | 6 - 4 | Hertha Berlin | 06:00 |
| Holstein Kiel | 2 - 1 | SC Paderborn 07 | 06:00 |
| Sunderland | 5 - 0 | Southampton | 06:30 |
| Bordeaux | 2 - 4 | Auxerre | 08:00 |
| Leicester | 0 - 1 | Hull City | 09:00 |
| Leeds | 0 - 0 | Sheffield Wednesday | 09:00 |
| Coventry | 3 - 3 | Watford | 09:00 |
| West Brom | 1 - 2 | Huddersfield | 09:00 |
| Rotherham | 2 - 1 | Norwich | 09:00 |
| Angers | 2 - 0 | Paris FC | 12:00 |
| Ajaccio | 2 - 2 | Dunkerque | 12:00 |
| Estac Troyes | 2 - 2 | Quevilly | 12:00 |
| Saint Etienne | 0 - 0 | Valenciennes | 12:00 |
| Leon | 1 - 1 | Necaxa | 18:00 |
| Santos Laguna | 2 - 1 | U.N.A.M. - Pumas | 20:00 |
| Tigres UANL | 5 - 0 | Club Queretaro | 20:05 |
| Cruz Azul | 2 - 3 | Club America | 22:10 |
| Pumas UNAM W | 2 - 1 | León W | 13:00 |
| Tacuary | 1 - 1 | Cerro Porteño | 16:00 |
| Querétaro W | 1 - 2 | Toluca W | 18:06 |
| Libertad | 2 - 0 | Sportivo Luqueno | 18:30 |
| Libertad | 0 - 1 | Mushuc Runa SC | 13:00 |
| Universidad Catolica | 1 - 1 | El Nacional | 15:30 |
| Emelec | 0 - 0 | Aucas | 18:00 |
| Goias | 0 - 0 | Internacional | 14:00 |
| Atletico Paranaense | 1 - 1 | Atletico-MG | 14:00 |
| Botafogo | 1 - 2 | Flamengo | 19:00 |
| Universidad de Chile | 1 - 1 | Colo Colo | 14:00 |
| Huachipato | 3 - 0 | Curico Unido | 17:00 |
| Gimnasia L.P. | 1 - 2 | Independiente | 13:00 |
| Lanus | 2 - 2 | Godoy Cruz | 14:30 |
| Huracan | 2 - 1 | Colon Santa Fe | 17:00 |
| Belgrano | 1 - 1 | Newells Old Boys | 17:00 |
| Velez Sarsfield | 2 - 0 | River Plate | 19:30 |
| Alianza Atletico | 1 - 1 | Carlos A. Mannucci | 13:00 |
| Cusco | 1 - 0 | ADT | 15:15 |
| Jaguares | 1 - 1 | Independiente Medellin | 16:45 |
| Santa Fe | 1 - 0 | Junior | 18:10 |
| Alianza Petrolera | 2 - 3 | America de Cali | 20:20 |
| New York City FC | 1 - 1 | Vancouver Whitecaps | 14:30 |
| Montreal Impact | 2 - 4 | Columbus Crew | 18:30 |
| DC United | 4 - 0 | Chicago Fire | 18:30 |
| FC Cincinnati | 0 - 1 | Orlando City SC | 18:30 |
| New England Revolution | 2 - 2 | Austin | 18:30 |
| Sporting Kansas City | 2 - 1 | St. Louis City | 19:30 |
| Nashville SC | 1 - 1 | Charlotte | 19:30 |
| FC Dallas | 2 - 2 | Atlanta United FC | 19:30 |
| Real Salt Lake | 2 - 0 | Colorado Rapids | 20:30 |
| Seattle Sounders | 2 - 2 | Portland Timbers | 21:30 |
| San Jose Earthquakes | 1 - 1 | Minnesota Stars FC | 21:30 |
| Los Angeles Galaxy | 0 - 0 | Houston Dynamo | 21:30 |
| Brown DE Adrogue | 1 - 1 | Deportivo Maipu | 11:10 |
| CA Estudiantes | 1 - 0 | Villa Dalmine | 13:00 |
| Quilmes | 0 - 1 | Independ. Rivadavia | 17:10 |
| Defensores Unidos | 1 - 0 | Almagro | 13:00 |
| Club Atlético Güemes | 1 - 0 | Estudiantes de Rio Cuarto | 13:30 |
| Patronato | 3 - 2 | All Boys | 15:10 |
