| Viernes 01 de Septiembre |
| Catania | 0 - 1 | Crotone | 12:45 |
| Sassuolo | 3 - 1 | Verona | 11:30 |
| Borussia Dortmund | 2 - 2 | FC Heidenheim | 13:30 |
| AS Roma | 1 - 2 | AC Milan | 13:45 |
| Wanderers | 2 - 1 | Torque | 17:00 |
| Avranches | 2 - 0 | Nimes | 12:30 |
| Cadiz | 3 - 1 | Villarreal | 12:30 |
| Chateauroux | 2 - 0 | Dijon | 12:30 |
| Jong Utrecht | 1 - 0 | Roda | 13:00 |
| MVV | 2 - 1 | Jong Ajax | 13:00 |
| FC OSS | 0 - 2 | Groningen | 13:00 |
| Telstar | 0 - 1 | FC Eindhoven | 13:00 |
| Emmen | 2 - 4 | Dordrecht | 13:00 |
| VVV Venlo | 2 - 0 | De Graafschap | 13:00 |
| Sparta Rotterdam | 1 - 1 | NEC Nijmegen | 13:00 |
| Helmond Sport | 2 - 1 | Cambuur | 13:00 |
| Nantes | 1 - 1 | Marseille | 14:00 |
| Luton | 1 - 2 | West Ham | 14:00 |
| Vizela | 1 - 0 | Gil Vicente | 14:15 |
| Albacete | 2 - 0 | Valladolid | 14:30 |
| Almeria | 2 - 3 | Celta Vigo | 15:00 |
| Leones Negros UDG | 0 - 0 | Monarcas | 22:05 |
| Atlético Saltillo | 1 - 1 | Durango | 20:00 |
| FC Juarez | 3 - 1 | Mazatlán | 20:06 |
| Puebla | 3 - 0 | Club Tijuana | 22:10 |
| Guairena FC | 2 - 1 | General Caballero | 18:00 |
| Delfin SC | 1 - 0 | Independiente del Valle | 19:00 |
| Juventud | 1 - 0 | Cerrito | 13:15 |
| Union La Calera | 1 - 1 | Deportes Copiapo | 18:00 |
| Central Cordoba de Santiago | 3 - 2 | Platense | 19:00 |
| Chico | 1 - 0 | Envigado | 18:05 |
| Deportes Tolima | 0 - 0 | Bucaramanga | 20:10 |
