| Local | Visita | Hora | |
|---|---|---|---|
| Lunes 28 de Agosto | |||
| Salernitana | 1 - 1 | Udinese | 11:30 |
| Cagliari | 0 - 2 | Inter | 13:45 |
| Eldense | 2 - 1 | Eibar | 12:00 |
| Getafe | 1 - 0 | Alaves | 12:30 |
| Rio Ave | 1 - 2 | FC Porto | 14:15 |
| Racing Santander | 0 - 0 | Huesca | 14:30 |
| Rayo Vallecano | 0 - 7 | Atletico Madrid | 14:30 |
| Annecy | 1 - 1 | Saint Etienne | 13:45 |
| Durango | 2 - 0 | Cimarrones de Sonora II | 21:00 |
| Pachuca | 0 - 2 | Atletico San Luis | 22:10 |
| Resistencia | 2 - 1 | Nacional Asuncion | 18:00 |
| Toluca W | 2 - 0 | Necaxa W | 18:00 |
| Santos Laguna W | 0 - 3 | Tijuana W | 20:06 |
| Deportivo Cuenca | 1 - 1 | Tecnico Universitario | 19:00 |
| Rentistas | 1 - 0 | Albion FC | 17:00 |
| Everton de Vina | 2 - 2 | Cobresal | 18:00 |
| Banfield | 3 - 0 | Rosario Central | 18:00 |
| Atletico Tucuman | 0 - 0 | Instituto Cordoba | 19:30 |
| ADT | 0 - 0 | UTC | 13:00 |
| Deportivo Garcilaso | 1 - 0 | Cesar Vallejo | 15:15 |
| Independiente Medellin | 1 - 1 | Chico | 18:15 |
| Bucaramanga | 1 - 0 | Deportivo Cali | 20:30 |
| All Boys | 3 - 1 | Gimnasia M. | 19:10 |
