| Local | Visita | Hora | |
|---|---|---|---|
| Miércoles 23 de Agosto | |||
| Villa Mitre | 0 - 0 | Chaco For Ever | 12:00 |
| Hibernian | 0 - 5 | Aston Villa | 11:45 |
| SC Braga | 2 - 1 | Panathinaikos | 14:00 |
| Cobreloa | 4 - 2 | Cobresal | 17:30 |
| Club America | 3 - 2 | Necaxa | 20:00 |
| Mineros de Zacatecas | 4 - 1 | Tepatitlán | 20:05 |
| Pachuca | 1 - 0 | Cruz Azul | 20:06 |
| Atletico San Luis | 3 - 0 | Leon | 22:00 |
| Cimarrones | 4 - 2 | Alebrijes de Oaxaca | 22:05 |
| FC Cincinnati | 3 - 3 | Inter Miami | 18:00 |
| Houston Dynamo | 3 - 1 | Real Salt Lake | 20:30 |
| Botafogo | 1 - 1 | Defensa Y Justicia | 17:00 |
| Boca Juniors | 0 - 0 | Racing Club | 19:30 |
| Deportivo Pereira | 0 - 4 | Palmeiras | 19:30 |
| Vargas Torres | 1 - 1 | Imbabura | 15:00 |
| 9 de Octubre | 1 - 0 | America de Quito | 15:00 |
| Chacaritas | 1 - 2 | Macara | 19:00 |
| Alianza Petrolera | 1 - 0 | La Equidad | 16:45 |
| Santa Fe | 2 - 0 | Envigado | 18:15 |
| Junior | 4 - 3 | America de Cali | 20:30 |
| Los Angeles FC | 4 - 0 | Colorado Rapids | 21:30 |
