| Local | Visita | Hora | |
|---|---|---|---|
| Martes 22 de Agosto | |||
| Castellón | CANC | Levante | 14:45 |
| SSV ULM 1846 | 1 - 0 | Arminia Bielefeld | 12:00 |
| Rangers | 2 - 2 | PSV Eindhoven | 14:00 |
| Celaya | 0 - 0 | Atlante FC | 18:05 |
| Mazatlán | 1 - 0 | Puebla | 20:00 |
| Guadalajara Chivas | 1 - 0 | Club Tijuana | 20:00 |
| CA La Paz | 3 - 0 | Leones Negros UDG | 20:05 |
| Venados FC | 4 - 3 | Correcaminos Uat | 22:05 |
| FC Juarez | 4 - 1 | U.N.A.M. - Pumas | 22:06 |
| Corinthians | 1 - 0 | Estudiantes L.P. | 19:30 |
| Bolívar | 0 - 1 | Internacional | 17:00 |
| UT Cotopaxi | 0 - 0 | Manta FC | 19:00 |
| Jaguares | 0 - 1 | Union Magdalena | 18:15 |
| San Martin S.J. | 0 - 0 | San Martin Tucuman | 14:30 |
