| Lunes 21 de Agosto |
| Torino | 0 - 0 | Cagliari | 11:30 |
| Bologna | 0 - 2 | AC Milan | 13:45 |
| Le Mans | 1 - 1 | Dijon | 11:30 |
| Alaves | 4 - 3 | Sevilla | 12:00 |
| Jong Utrecht | 1 - 0 | Groningen | 13:00 |
| Jong Ajax | 1 - 2 | De Graafschap | 13:00 |
| Crystal Palace | 0 - 1 | Arsenal | 14:00 |
| Famalicao | 0 - 0 | Moreirense | 14:15 |
| Huesca | 0 - 2 | Tenerife | 14:30 |
| Granada CF | 0 - 2 | Rayo Vallecano | 14:30 |
| Leixões | 0 - 0 | Santa Clara | 14:45 |
| Ajaccio | 0 - 0 | Bordeaux | 13:45 |
| Cruz Azul W | 1 - 5 | Guadalajara W | 16:45 |
| Tacuary | 1 - 0 | Resistencia | 18:00 |
| Pumas UNAM W | 4 - 1 | Mazatlán W | 18:00 |
| Necaxa W | 0 - 2 | Querétaro W | 18:00 |
| León W | 2 - 3 | América W | 20:06 |
| Monterrey W | 2 - 2 | Juárez W | 22:00 |
| Santos Laguna W | 0 - 7 | Tigres UANL W | 22:10 |
| Goias | 1 - 1 | Atletico Paranaense | 18:00 |
| Huracan | 2 - 0 | Banfield | 16:00 |
| Central Cordoba de Santiago | 2 - 0 | Newells Old Boys | 18:30 |
| Sport Boys | 1 - 1 | Atletico Grau | 13:00 |
| UTC | 3 - 2 | Deportivo Binacional | 15:15 |
| Cesar Vallejo | 1 - 1 | ADT | 18:00 |
| Bucaramanga | 1 - 1 | Rionegro Aguilas | 16:00 |
| Millonarios | 2 - 1 | Once Caldas | 19:00 |
| Defensores Unidos | 1 - 1 | Temperley | 13:00 |
| Flandria | 0 - 1 | Nueva Chicago | 13:30 |
| Gimnasia M. | 1 - 0 | Estudiantes de Rio Cuarto | 18:45 |
| Club Atlético Güemes | 0 - 0 | Almirante Brown | 19:10 |
