| Martes 15 de Agosto |
| Numancia | 1 - 3 | Eibar | 11:30 |
| Colon Santa Fe | 2 - 0 | Lanus | 15:00 |
| Independiente | 0 - 0 | Central Cordoba de Santiago | 19:30 |
| Baka Topola | 1 - 4 | SC Braga | 13:00 |
| Sturm Graz | 1 - 3 | PSV Eindhoven | 13:30 |
| Marseille | 2 - 1 | Panathinaikos | 14:00 |
| OHiggins | 3 - 2 | Magallanes | 14:00 |
| Alebrijes de Oaxaca | 2 - 1 | Celaya | 20:05 |
| Dorados | 4 - 0 | Mineros de Zacatecas | 22:05 |
| Philadelphia Union | 1 - 4 | Inter Miami | 18:00 |
| Monterrey | 0 - 2 | Nashville SC | 20:30 |
| Atletico Paranaense | 2 - 0 | Cuiaba | 18:00 |
| Nublense | 1 - 1 | Union La Calera | 11:30 |
| Manta FC | 0 - 1 | Vargas Torres | 16:30 |
| Macara | 2 - 0 | Cuniburo | 19:00 |
| Union Comercio | 2 - 0 | Cienciano | 13:00 |
| Academia Cantolao | 1 - 0 | Alianza Atletico | 15:15 |
| FBC Melgar | 1 - 1 | UTC | 18:00 |
| Estudiantes de Rio Cuarto | 1 - 1 | Alvarado | 11:30 |
| San Telmo | 0 - 1 | Agropecuario | 13:00 |
| Defensores De Belgrano | 1 - 0 | Gimnasia M. | 17:05 |
| Almirante Brown | 2 - 0 | Patronato | 17:10 |
| All Boys | 1 - 0 | Flandria | 18:00 |
| Temperley | 0 - 0 | Guillermo Brown | 18:00 |
