| Local | Visita | Hora | |
|---|---|---|---|
| Lunes 31 de Julio | |||
| Everton de Vina | 2 - 2 | Monza | 19:00 |
| Willem II | 2 - 1 | Almere City FC | 19:00 |
| Alebrijes de Oaxaca | 1 - 1 | Tapatío | 20:05 |
| León W | 2 - 0 | Querétaro W | 20:06 |
| Chicago Fire | 1 - 1 | Puebla | 19:00 |
| Columbus Crew | 1 - 4 | Club America | 19:00 |
| Colorado Rapids | 4 - 1 | Toluca | 20:30 |
| Sporting Kansas City | 0 - 1 | Guadalajara Chivas | 21:00 |
| Sport Boys | 0 - 2 | FBC Melgar | 13:00 |
| Sport Huancayo | 2 - 0 | Alianza Atletico | 15:15 |
| Universitario | 3 - 0 | Carlos A. Mannucci | 20:30 |
| Envigado | 0 - 0 | Union Magdalena | 16:00 |
| Chico | 0 - 2 | La Equidad | 18:10 |
| Junior | 1 - 1 | Bucaramanga | 20:20 |
| Defensores De Belgrano | 4 - 2 | Flandria | 13:00 |
| All Boys | 1 - 0 | Defensores Unidos | 19:10 |
