| Local | Visita | Hora | |
|---|---|---|---|
| Lunes 22 de Mayo | |||
| Cruzeiro | 0 - 1 | Cuiaba | 18:00 |
| UT Cotopaxi | 1 - 1 | Cuniburo | 19:00 |
| Sport Boys | 3 - 2 | UTC | 15:30 |
| Club Guarani | 0 - 2 | Sportivo Trinidense | 09:00 |
| Resistencia | 1 - 0 | Tacuary | 09:00 |
| Sportivo Ameliano | 1 - 1 | Guairena FC | 16:00 |
| Sportivo Luqueno | 0 - 1 | Nacional Asuncion | 18:30 |
| Alianza Petrolera | 5 - 3 | Rionegro Aguilas | 18:00 |
| Racing Cordoba | 1 - 1 | Ferro Carril Oeste | 17:00 |
| Atlanta | 1 - 2 | Gimnasia Jujuy | 18:35 |
| All Boys | 2 - 1 | Defensores De Belgrano | 19:10 |
| FC Eindhoven | 1 - 0 | Almere City FC | 13:00 |
| AS Roma | 2 - 2 | Salernitana | 11:30 |
| Empoli | 4 - 1 | Juventus | 13:45 |
| LE Havre | 0 - 2 | Valenciennes | 13:45 |
| Newcastle | 0 - 0 | Leicester | 14:00 |
| América W | 5 - 1 | Juárez W | 18:00 |
| Tigres UANL W | 2 - 0 | Atlas W | 20:00 |
| Monterrey W | 6 - 1 | Tijuana W | 22:00 |
