| Local | Visita | Hora | |
|---|---|---|---|
| Lunes 15 de Mayo | |||
| FBC Melgar | 2 - 4 | Deportivo Garcilaso | 15:30 |
| Alianza Lima | 2 - 1 | Deportivo Municipal | 20:00 |
| Tecnico Universitario | 0 - 0 | Cumbayá | 19:00 |
| Universidad de Chile | 0 - 0 | Cobresal | 17:00 |
| OHiggins | 1 - 1 | Everton de Vina | 19:30 |
| Boston River | 1 - 1 | Plaza Colonia | 13:00 |
| Cerro | 1 - 0 | Racing Montevideo | 17:00 |
| Barracas Central | 2 - 2 | Central Cordoba de Santiago | 13:30 |
| Union Santa Fe | 0 - 2 | Sarmiento Junin | 13:30 |
| Gimnasia L.P. | 1 - 0 | Lanus | 16:00 |
| Velez Sarsfield | 0 - 0 | Rosario Central | 18:30 |
| Alianza Petrolera | 2 - 1 | Atletico Nacional | 18:20 |
| Deportivo Riestra | 2 - 2 | Racing Cordoba | 13:30 |
| CA Estudiantes | 3 - 0 | Chaco For Ever | 19:10 |
| Club Atlético Güemes | 0 - 1 | San Martin Tucuman | 17:00 |
| San Martin S.J. | 2 - 1 | Guillermo Brown | 19:30 |
| Estoril | 2 - 0 | Arouca | 14:15 |
| Real Betis | 3 - 1 | Rayo Vallecano | 14:00 |
| Sampdoria | 1 - 1 | Empoli | 13:45 |
| Annecy | 1 - 0 | LE Havre | 13:45 |
| Leicester | 0 - 3 | Liverpool | 14:00 |
| Mazatlán W | 0 - 2 | Querétaro W | 20:00 |
| Atlas W | 2 - 2 | León W | 20:05 |
| Monterrey W | 4 - 2 | Atlético San Luis W | 22:00 |
| Levante | 0 - 0 | Ibiza | 14:00 |
