| Local | Visita | Hora | |
|---|---|---|---|
| Jueves 11 de Mayo | |||
| Lanus | 3 - 1 | Sol de Mayo | 18:05 |
| Coritiba | 1 - 1 | Vasco DA Gama | 17:00 |
| Botafogo | 3 - 0 | Corinthians | 17:30 |
| Fortaleza EC | 0 - 0 | Sao Paulo | 18:00 |
| Alianza Lima | 2 - 0 | Cesar Vallejo | 20:00 |
| Manta FC | 1 - 0 | Chacaritas | 19:00 |
| AS Roma | 1 - 0 | Bayer Leverkusen | 14:00 |
| Juventus | 1 - 1 | Sevilla | 14:00 |
| Everton de Vina | 2 - 2 | Palestino | 19:30 |
| Santa Fe | 0 - 2 | Atletico Nacional | 20:00 |
| West Ham | 2 - 1 | AZ Alkmaar | 14:00 |
| Fiorentina | 1 - 2 | FC Basel 1893 | 14:00 |
| Independiente Medellin | 2 - 2 | Once Caldas | 18:00 |
| General Caballero | 3 - 0 | Guairena FC | 18:00 |
| Atlas | 1 - 0 | Guadalajara Chivas | 20:00 |
| Tigres UANL | 4 - 1 | Toluca | 22:10 |
| Monarcas | 1 - 1 | Celaya | 18:00 |
