| Local | Visita | Hora | |
|---|---|---|---|
| Miércoles 10 de Mayo | |||
| Barracas Central | 1 - 0 | CA Estudiantes | 19:10 |
| York 9 FC | 1 - 4 | Vancouver Whitecaps | 18:30 |
| Millonarios | 3 - 1 | Alianza Petrolera | 20:10 |
| FC Cincinnati | 1 - 0 | New York City FC | 18:00 |
| Loudoun United | 1 - 5 | Columbus Crew | 18:00 |
| Nashville SC | 2 - 0 | FC Dallas | 19:30 |
| Houston Dynamo | 1 - 0 | Sporting Kansas City | 19:30 |
| Austin | 2 - 0 | New Mexico United | 20:00 |
| Portland Timbers | 3 - 4 | Real Salt Lake | 21:30 |
| Los Angeles Galaxy | 3 - 1 | Seattle Sounders | 21:30 |
| Bragantino | 2 - 2 | America Mineiro | 17:00 |
| Santos | 3 - 0 | Bahia | 17:00 |
| Internacional | 0 - 2 | Atletico Paranaense | 17:00 |
| Flamengo | 2 - 0 | Goias | 18:00 |
| Union Magdalena | 0 - 0 | Chico | 18:00 |
| Cuiaba | 0 - 4 | Atletico-MG | 18:00 |
| Cruzeiro | 0 - 2 | Fluminense | 19:30 |
| Palmeiras | 4 - 1 | Gremio | 19:30 |
| Cienciano | 5 - 2 | Alianza Atletico | 15:30 |
| America de Quito | 1 - 0 | Guayaquil | 19:00 |
| Macara | 2 - 1 | UT Cotopaxi | 19:00 |
| Imbabura | 2 - 0 | Cuniburo | 19:00 |
| Cobresal | 1 - 0 | OHiggins | 17:00 |
| Coquimbo Unido | 2 - 1 | Universidad de Chile | 17:00 |
| U. Catolica | 1 - 2 | Huachipato | 19:30 |
| Santos Laguna | 0 - 0 | Monterrey | 20:00 |
| Atletico San Luis | 1 - 3 | Club America | 22:10 |
| Atlante FC | 0 - 0 | Tapatío | 18:00 |
| AC Milan | 0 - 2 | Inter | 14:00 |
