| Sábado 22 de Abril |
| Fluminense | 2 - 0 | Atletico Paranaense | 14:00 |
| Cuiaba | 1 - 1 | Bragantino | 16:30 |
| Sao Paulo | 3 - 0 | America Mineiro | 16:30 |
| Cruzeiro | 1 - 0 | Gremio | 19:00 |
| Gualaceo SC | 1 - 0 | Universidad Catolica | 13:00 |
| Progreso | 1 - 0 | Albion FC | 13:15 |
| Independiente del Valle | 1 - 0 | Tecnico Universitario | 15:30 |
| Orense SC | 2 - 1 | LDU de Quito | 18:00 |
| Huachipato | 2 - 3 | Union La Calera | 14:00 |
| Everton de Vina | 1 - 2 | Universidad de Chile | 16:30 |
| U. Catolica | 0 - 1 | OHiggins | 19:00 |
| Torque | 1 - 1 | Boston River | 10:30 |
| La Luz | 2 - 2 | River Plate | 16:00 |
| Defensor Sporting | 1 - 1 | Deportivo Maldonado | 18:30 |
| Philadelphia Union | 4 - 2 | Toronto FC | 18:30 |
| Academia Cantolao | 0 - 2 | Carlos A. Mannucci | 13:00 |
| Lanus | 2 - 1 | Sarmiento Junin | 13:30 |
| Arsenal Sarandi | 2 - 1 | Union Santa Fe | 13:30 |
| Sport Huancayo | 1 - 3 | ADT | 15:30 |
| Cienciano | 1 - 1 | Deportivo Binacional | 18:00 |
| Orlando City SC | 1 - 3 | DC United | 18:30 |
| New York City FC | 3 - 1 | FC Dallas | 18:30 |
| Belgrano | 1 - 0 | Newells Old Boys | 18:30 |
| New England Revolution | 2 - 1 | Sporting Kansas City | 18:30 |
| Montreal Impact | 2 - 0 | New York Red Bulls | 18:30 |
| Central Cordoba de Santiago | 0 - 2 | Godoy Cruz | 18:30 |
| FC Cincinnati | 2 - 1 | Portland Timbers | 18:30 |
| Charlotte | 1 - 0 | Columbus Crew | 18:30 |
| Houston Dynamo | 1 - 0 | Inter Miami | 19:30 |
| Nashville SC | 1 - 1 | Los Angeles FC | 19:30 |
| Colorado Rapids | 1 - 1 | St. Louis City | 20:30 |
| Real Salt Lake | 3 - 1 | San Jose Earthquakes | 20:30 |
| Sportivo Trinidense | 1 - 0 | Guairena FC | 16:00 |
| Resistencia | 1 - 1 | Sportivo Ameliano | 18:30 |
| Seattle Sounders | 1 - 0 | Minnesota Stars FC | 21:30 |
| Los Angeles Galaxy | 2 - 0 | Austin | 21:30 |
| La Equidad | 2 - 1 | Huila | 14:00 |
| Alianza Petrolera | 0 - 3 | Deportivo Cali | 16:10 |
| Santa Fe | 3 - 0 | Bucaramanga | 20:30 |
| Deportivo Madryn | 0 - 1 | Atletico DE Rafaela | 13:30 |
| Chacarita Juniors | 4 - 2 | Deportivo Riestra | 15:30 |
| Villa Dalmine | 1 - 0 | CA Estudiantes | 17:00 |
| Aldosivi | 0 - 1 | Atlanta | 17:35 |
| Manchester City | 3 - 0 | Sheffield Utd | 10:45 |
| Agropecuario | 1 - 0 | Guillermo Brown | 13:30 |
| Nueva Chicago | 2 - 2 | Gimnasia M. | 13:30 |
| Estudiantes de Rio Cuarto | 1 - 1 | Club Atlético Güemes | 18:10 |
| All Boys | 0 - 1 | Patronato | 19:40 |
| Hansa Rostock | 2 - 0 | SpVgg Greuther Furth | 06:00 |
| Arminia Bielefeld | 1 - 3 | Hannover 96 | 06:00 |
| 1899 Hoffenheim | 1 - 3 | FC Koln | 08:30 |
| FSV Mainz 05 | 3 - 1 | Bayern Munich | 08:30 |
| Hertha Berlin | 2 - 4 | Werder Bremen | 08:30 |
| VfL BOCHUM | 1 - 5 | VfL Wolfsburg | 08:30 |
| Farense | 2 - 1 | Penafiel | 09:30 |
| Famalicao | 3 - 2 | Marítimo | 09:30 |
| Borussia Dortmund | 4 - 0 | Eintracht Frankfurt | 11:30 |
| Boavista | 3 - 2 | Rio Ave | 12:00 |
| Paços de Ferreira | 0 - 2 | FC Porto | 14:30 |
| Osasuna | 3 - 2 | Real Betis | 07:00 |
| Almeria | 1 - 2 | Athletic Club | 09:15 |
| Valladolid | 1 - 0 | Girona | 11:30 |
| Real Sociedad | 2 - 1 | Rayo Vallecano | 11:30 |
| Heerenveen | 2 - 3 | Emmen | 11:45 |
| Real Madrid | 2 - 0 | Celta Vigo | 14:00 |
| Vitesse | 0 - 0 | Excelsior | 14:00 |
| Salernitana | 3 - 0 | Sassuolo | 08:00 |
| Lazio | 0 - 1 | Torino | 11:00 |
| Sampdoria | 1 - 1 | Spezia | 13:45 |
| Fulham | 2 - 1 | Leeds | 06:30 |
| Saint Etienne | 1 - 3 | Metz | 08:00 |
| Brentford | 1 - 1 | Aston Villa | 09:00 |
| Liverpool | 3 - 2 | Nottingham Forest | 09:00 |
| Leicester | 2 - 1 | Wolves | 09:00 |
| Crystal Palace | 0 - 0 | Everton | 09:00 |
| Auxerre | 1 - 1 | Lille | 10:00 |
| LE Havre | 0 - 0 | Quevilly | 12:00 |
| Dijon | 1 - 1 | Bastia | 12:00 |
| Paris FC | 3 - 0 | Nimes | 12:00 |
| Lens | 3 - 0 | Monaco | 14:00 |
| Frosinone | 0 - 0 | Sudtirol | 07:00 |
| Cittadella | 0 - 1 | Genoa | 07:00 |
| Parma | 2 - 1 | Cagliari | 07:00 |
| Palermo | 1 - 1 | Benevento | 09:15 |
| Cruz Azul W | 0 - 2 | Guadalajara W | 13:00 |
| Las Palmas | 0 - 0 | Levante | 11:30 |
| Pachuca | 2 - 1 | Atletico San Luis | 18:00 |
| Guadalajara Chivas | 2 - 1 | Cruz Azul | 20:05 |
| Club America | 1 - 1 | U.N.A.M. - Pumas | 22:10 |
| Norwich | 0 - 3 | Swansea | 09:00 |
| Hull City | 1 - 0 | Watford | 09:00 |
| Burnley | 1 - 2 | QPR | 09:00 |
