| Local | Visita | Hora | |
|---|---|---|---|
| Lunes 17 de Abril | |||
| Emelec | 1 - 2 | El Nacional | 16:30 |
| Universidad Catolica | 1 - 1 | Orense SC | 19:00 |
| Curico Unido | 0 - 1 | Union Espanola | 19:30 |
| Deportivo Maldonado | 4 - 2 | La Luz | 17:15 |
| Platense | 0 - 0 | Colon Santa Fe | 14:30 |
| Sarmiento Junin | 1 - 0 | Arsenal Sarandi | 17:00 |
| Banfield | 1 - 0 | Central Cordoba de Santiago | 17:00 |
| Godoy Cruz | 4 - 4 | Lanus | 19:30 |
| Atletico Tucuman | 2 - 2 | Rosario Central | 19:30 |
| Libertad | 4 - 0 | Resistencia | 17:00 |
| General Caballero | 3 - 2 | Sportivo Luqueno | 19:30 |
| Huila | 1 - 1 | Deportivo Pasto | 19:40 |
| Deportivo Riestra | 0 - 0 | Atletico Mitre | 13:30 |
| Atlanta | 3 - 2 | Tristan Suarez | 17:40 |
| Racing Cordoba | 1 - 1 | Chacarita Juniors | 19:40 |
| Vilafranquense | 0 - 1 | Estrela | 14:15 |
| Vizela | 1 - 1 | Boavista | 14:15 |
| Celta Vigo | 0 - 1 | Mallorca | 14:00 |
| Fiorentina | 1 - 1 | Atalanta | 13:45 |
| Grenoble | 0 - 2 | Saint Etienne | 13:45 |
| Leeds | 1 - 6 | Liverpool | 14:00 |
| Toluca W | 2 - 0 | Monterrey W | 18:00 |
| Guadalajara W | 3 - 0 | León W | 18:05 |
| Tigres UANL W | 5 - 0 | Mazatlán W | 20:00 |
| Pachuca W | 5 - 1 | Necaxa W | 20:06 |
| Santos Laguna W | 3 - 2 | Juárez W | 22:10 |
| Levante | 1 - 2 | Mirandes | 14:00 |
