| Local | Visita | Hora | |
|---|---|---|---|
| Lunes 20 de Marzo | |||
| Deportivo Cuenca | 1 - 0 | Cumbayá | 18:00 |
| Cerro | 2 - 0 | Fenix | 16:15 |
| General Caballero | 2 - 3 | Cerro Porteño | 15:00 |
| Newells Old Boys | 1 - 0 | San Lorenzo | 15:30 |
| Tacuary | 2 - 0 | Resistencia | 17:30 |
| Lanus | 0 - 0 | Argentinos JRS | 18:00 |
| Huracan | 0 - 2 | Rosario Central | 18:00 |
| Cusco | 3 - 0 | Carlos A. Mannucci | 14:30 |
| Huila | 2 - 1 | Once Caldas | 19:20 |
| Deportivo Riestra | 2 - 1 | Villa Dalmine | 13:00 |
| Goias | 3 - 0 | Anápolis | 16:00 |
| Deportivo Moron | 1 - 1 | Alvarado | 18:10 |
| Água Santa | 1 - 1 | Bragantino | 18:00 |
| Necaxa W | 2 - 3 | Tijuana W | 17:00 |
| Santos Laguna W | 0 - 2 | Toluca W | 17:05 |
| Tigres UANL W | 1 - 0 | América W | 19:00 |
| Pachuca W | 2 - 0 | Mazatlán W | 19:06 |
| Mirandes | 2 - 3 | Eibar | 14:00 |
