| Local | Visita | Hora | |
|---|---|---|---|
| Lunes 27 de Febrero | |||
| Delfin SC | 1 - 1 | Orense SC | 18:00 |
| Portland Timbers | 1 - 0 | Sporting Kansas City | 21:00 |
| La Luz | 1 - 1 | Torque | 15:30 |
| Wanderers | 1 - 1 | Liverpool | 18:00 |
| Barracas Central | 1 - 0 | Gimnasia L.P. | 14:00 |
| Racing Club | 2 - 1 | Lanus | 16:15 |
| Central Cordoba de Santiago | 1 - 0 | Argentinos JRS | 18:30 |
| Academia Cantolao | 2 - 3 | Cusco | 14:30 |
| Atletico Nacional | 3 - 1 | Huila | 16:00 |
| Chico | 1 - 1 | Deportivo Pasto | 17:00 |
| Deportes Tolima | 1 - 2 | Deportivo Cali | 17:20 |
| Everton de Vina | 3 - 1 | A. Italiano | 17:30 |
| Deportes Copiapo | 2 - 2 | OHiggins | 17:30 |
| Agropecuario | 2 - 1 | Defensores De Belgrano | 18:10 |
| Vasco DA Gama | 4 - 1 | Boavista SC | 16:30 |
| Sporting CP | 2 - 0 | Estoril | 13:00 |
| Guimaraes | 2 - 1 | SC Braga | 15:15 |
| Villarreal | 2 - 1 | Getafe | 14:00 |
| Verona | 0 - 3 | Fiorentina | 11:30 |
| Lazio | 1 - 0 | Sampdoria | 13:45 |
| Amiens | 1 - 2 | Bordeaux | 13:45 |
| MVV | 3 - 2 | PEC Zwolle | 13:00 |
| Monterrey W | 3 - 0 | Necaxa W | 17:05 |
| Mazatlán W | 0 - 6 | Guadalajara W | 19:00 |
| Pachuca W | 2 - 1 | Tigres UANL W | 19:06 |
| Granada CF | 1 - 0 | Malaga | 14:00 |
| Leon | 1 - 1 | Monterrey | 21:10 |
