| Local | Visita | Hora | |
|---|---|---|---|
| Jueves 19 de Mayo | |||
| Primero de Mayo | 0 - 1 | El Nacional | 19:00 |
| Union Santa Fe | 0 - 0 | Fluminense | 17:15 |
| Independiente | 4 - 0 | Deportivo La Guaira | 17:15 |
| Sao Paulo | 3 - 0 | Jorge Wilstermann | 19:30 |
| Metropolitanos FC | 2 - 2 | Barcelona SC | 19:30 |
| Lanus | 1 - 2 | Wanderers | 19:30 |
| Atyrá | 0 - 1 | Sportivo Luqueno | 14:00 |
| Gremio | 0 - 0 | Criciuma | 17:00 |
| Atletico-MG | 3 - 1 | Independiente del Valle | 17:00 |
| River Plate | 4 - 0 | Colo Colo | 19:00 |
| Guarani Campinas | 0 - 0 | Vasco DA Gama | 19:30 |
| Deportivo Cali | 3 - 0 | Always Ready | 21:00 |
| UT Cotopaxi | 0 - 1 | CD Olmedo | 19:00 |
| Aston Villa | 1 - 1 | Burnley | 14:00 |
| Chelsea | 1 - 1 | Leicester | 14:00 |
| Everton | 3 - 2 | Crystal Palace | 13:45 |
| Hertha Berlin | 0 - 1 | Hamburger SV | 13:30 |
| Heerenveen | 3 - 2 | AZ Alkmaar | 11:45 |
| Utrecht | 3 - 1 | Vitesse | 14:00 |
| Club America | 1 - 1 | Pachuca | 20:00 |
