| Sábado 23 de Abril |
| Tombense | 1 - 1 | Cruzeiro | 17:00 |
| Atletico Paranaense | 1 - 0 | Flamengo | 14:30 |
| Bragantino | 1 - 1 | Sao Paulo | 14:30 |
| Molinos El Pirata | 0 - 2 | Union Comercio | 15:00 |
| Palmeiras | 3 - 0 | Corinthians | 17:00 |
| Fluminense | 0 - 1 | Internacional | 17:00 |
| Atletico-MG | 2 - 2 | Coritiba | 19:00 |
| Real Betis | 1 - 1 | Valencia | 15:00 |
| Wanderers | 0 - 0 | Liverpool | 11:30 |
| River Plate | 0 - 0 | Danubio | 14:00 |
| Gualaceo SC | 2 - 1 | Orense SC | 14:00 |
| Deportivo Cuenca | 1 - 1 | 9 de Octubre | 16:30 |
| Torque | 0 - 1 | Peñarol | 17:00 |
| Delfin SC | 0 - 1 | Independiente del Valle | 19:00 |
| Antofagasta | 0 - 0 | Huachipato | 11:30 |
| Defensores Unidos | 1 - 1 | Villa San Carlos | 13:30 |
| D. La Serena | 1 - 3 | Curico Unido | 14:00 |
| Philadelphia Union | 1 - 1 | Montreal Impact | 14:00 |
| FC Dallas | 2 - 1 | Houston Dynamo | 14:00 |
| Academia Cantolao | 1 - 2 | Alianza Lima | 15:30 |
| Minnesota Stars FC | 3 - 0 | Chicago Fire | 16:00 |
| Deportivo Binacional | 2 - 1 | Carlos A. Mannucci | 18:00 |
| DC United | 3 - 2 | New England Revolution | 18:30 |
| Sporting Kansas City | 0 - 0 | Columbus Crew | 19:30 |
| Austin | 3 - 0 | Vancouver Whitecaps | 19:30 |
| Colorado Rapids | 0 - 0 | Charlotte | 20:00 |
| Portland Timbers | 0 - 0 | Real Salt Lake | 21:00 |
| Los Angeles Galaxy | 1 - 0 | Nashville SC | 21:30 |
| Gimnasia L.P. | 1 - 0 | Union Santa Fe | 12:00 |
| San Lorenzo | 1 - 2 | Patronato | 12:00 |
| Brown DE Adrogue | 1 - 1 | Independ. Rivadavia | 13:00 |
| Atlanta | 0 - 0 | Estudiantes de Rio Cuarto | 13:30 |
| San Telmo | 3 - 1 | Temperley | 13:30 |
| Chacarita Juniors | 2 - 2 | Quilmes | 14:10 |
| Rosario Central | 3 - 0 | Independiente | 14:30 |
| San Martin S.J. | 3 - 2 | Deportivo Madryn | 14:30 |
| Libertad | 4 - 0 | 12 de Octubre | 16:30 |
| Tristan Suarez | 2 - 1 | Sacachispas | 17:00 |
| Central Cordoba de Santiago | 1 - 2 | Boca Juniors | 17:00 |
| Santamarina | 0 - 0 | Almagro | 17:45 |
| Chaco For Ever | 1 - 0 | Deportivo Moron | 19:00 |
| General Caballero | 2 - 3 | Olimpia | 19:15 |
| Banfield | 3 - 1 | Talleres Cordoba | 19:30 |
| Barracas Central | 1 - 1 | Velez Sarsfield | 19:30 |
| San Jose Earthquakes | 4 - 3 | Seattle Sounders | 21:00 |
| Bucaramanga | 2 - 3 | Independiente Medellin | 16:00 |
| Atletico Nacional | 0 - 0 | Once Caldas | 18:05 |
| Union Magdalena | 1 - 1 | Junior | 20:10 |
| NEC Nijmegen | 0 - 1 | Ajax | 09:30 |
| AZ Alkmaar | 2 - 1 | Heerenveen | 11:45 |
| Waalwijk | 0 - 2 | PEC Zwolle | 13:00 |
| Cambuur | 1 - 2 | PSV Eindhoven | 14:00 |
| Tapachula | 1 - 0 | Durango | 19:00 |
| Casa Pia | 3 - 0 | Estrela | 05:00 |
| Jahn Regensburg | 2 - 4 | Hamburger SV | 06:30 |
| Holstein Kiel | 1 - 1 | FC Heidenheim | 06:30 |
| FC Schalke 04 | 1 - 4 | Werder Bremen | 06:30 |
| Chaves | 3 - 2 | Académica | 08:00 |
| SpVgg Greuther Furth | 1 - 4 | Bayer Leverkusen | 08:30 |
| FC Koln | 3 - 1 | Arminia Bielefeld | 08:30 |
| SC Freiburg | 3 - 3 | Borussia Monchengladbach | 08:30 |
| Eintracht Frankfurt | 2 - 2 | 1899 Hoffenheim | 08:30 |
| RB Leipzig | 1 - 2 | Union Berlin | 08:30 |
| Portimonense | 1 - 0 | Moreirense | 09:30 |
| Bayern Munich | 3 - 1 | Borussia Dortmund | 11:30 |
| Santa Clara | 2 - 2 | Marítimo | 12:00 |
| Benfica | 0 - 0 | Famalicao | 12:00 |
| FC St. Pauli | 1 - 2 | SV Darmstadt 98 | 13:30 |
| Gil Vicente | 1 - 1 | Paços de Ferreira | 14:30 |
| Arsenal | 3 - 1 | Manchester United | 06:30 |
| Torino | 2 - 1 | Spezia | 08:00 |
| Venezia | 1 - 3 | Atalanta | 08:00 |
| Norwich | 0 - 3 | Newcastle | 09:00 |
| Manchester City | 5 - 1 | Watford | 09:00 |
| Leicester | 0 - 0 | Aston Villa | 09:00 |
| Lyon | 5 - 2 | Montpellier | 10:00 |
| Inter | 3 - 1 | AS Roma | 11:00 |
| Brentford | 0 - 0 | Tottenham | 11:30 |
| Saint Etienne | 1 - 4 | Monaco | 12:00 |
| Verona | 1 - 1 | Sampdoria | 13:45 |
| Paris Saint Germain | 1 - 1 | Lens | 14:00 |
| Caen | 1 - 1 | Auxerre | 08:00 |
| Atlas W | 0 - 1 | Guadalajara W | 12:00 |
| Pumas UNAM W | 2 - 1 | Atlético San Luis W | 12:00 |
| Malaga | 1 - 3 | Eibar | 11:30 |
| Pachuca | 3 - 0 | Monterrey | 17:00 |
| Tigres UANL | 0 - 2 | Club America | 19:00 |
| Guadalajara Chivas | 3 - 1 | U.N.A.M. - Pumas | 21:00 |
| Luton | 1 - 1 | Blackpool | 06:30 |
| Sheffield Utd | 1 - 0 | Cardiff | 09:00 |
| Peterborough | 0 - 1 | Nottingham Forest | 09:00 |
| Bournemouth | 1 - 1 | Fulham | 09:00 |
| West Brom | 0 - 0 | Coventry | 09:00 |
