| Local | Visita | Hora | |
|---|---|---|---|
| Jueves 10 de Marzo | |||
| Nacional Asuncion | 0 - 1 | Guairena FC | 16:15 |
| Union Espanola | 1 - 2 | Antofagasta | 16:15 |
| La Equidad | 0 - 0 | Junior | 18:30 |
| Wanderers | 2 - 1 | Cerro Largo | 18:30 |
| Delfin SC | 1 - 1 | 9 de Octubre | 18:30 |
| Pouso Alegre | 1 - 1 | Coritiba | 18:30 |
| Universidad Catolica | 0 - 0 | The Strongest | 18:30 |
| Villa Dalmine | 0 - 0 | Atlanta | 17:05 |
| Sao Paulo | 0 - 1 | Palmeiras | 17:30 |
| Chico | 2 - 2 | Valledupar | 17:00 |
| Vitesse | 0 - 1 | AS Roma | 11:45 |
| FK Partizan | 2 - 5 | Feyenoord | 11:45 |
| Bodo/Glimt | 2 - 1 | AZ Alkmaar | 14:00 |
| PSV Eindhoven | 4 - 4 | FC Copenhagen | 14:00 |
| Leicester | 2 - 0 | Rennes | 14:00 |
| Marseille | 2 - 1 | FC Basel 1893 | 14:00 |
| Wolves | 4 - 0 | Watford | 13:30 |
| Leeds | 0 - 3 | Aston Villa | 13:45 |
| Southampton | 1 - 2 | Newcastle | 13:30 |
| Norwich | 1 - 3 | Chelsea | 13:30 |
| Tapatío | 1 - 0 | Correcaminos Uat | 19:00 |
| Sevilla | 1 - 0 | West Ham | 11:45 |
| RB Leipzig | 0 - 0 | Spartak Moscow | 11:45 |
| Atalanta | 3 - 2 | Bayer Leverkusen | 14:00 |
| SC Braga | 2 - 0 | Monaco | 14:00 |
| Barcelona | 0 - 0 | Galatasaray | 14:00 |
